Evaluation of the Transwell System for Characterization of Dissolution Behavior of Inhalation Drugs: Effects of Membrane and Surfactant

Assessing the dissolution behavior of orally inhaled drug products (OIDs) has been proposed as an additional in vitro test for the characterization of innovator and generic drug development. A number of suggested dissolution methods (e.g., commercially available Transwell or Franz cell systems) have...

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Veröffentlicht in:	Molecular pharmaceutics 2015-08, Vol.12 (8), p.2618-2624
Hauptverfasser:	Rohrschneider, Marc, Bhagwat, Sharvari, Krampe, Raphael, Michler, Victoria, Breitkreutz, Jörg, Hochhaus, Günther
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Adrenal Cortex Hormones - administration & dosage Adrenal Cortex Hormones - pharmacokinetics Budesonide - administration & dosage Budesonide - pharmacokinetics Cells, Cultured Drugs, Generic - administration & dosage Drugs, Generic - pharmacokinetics Fluticasone - administration & dosage Fluticasone - pharmacokinetics Humans Membranes - drug effects Membranes - physiology Oral Sprays Pregnenediones - administration & dosage Pregnenediones - pharmacokinetics Respiratory Therapy - methods Respiratory Tract Absorption - drug effects Solubility Surface-Active Agents - pharmacology Tissue Culture Techniques - instrumentation Tissue Culture Techniques - methods
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