Selective Monoarylation of Primary Amines Using the Pd-PEPPSI-IPent(Cl) Precatalyst
A single set of reaction conditions for the palladium-catalyzed amination of a wide variety of (hetero)aryl halides using primary alkyl amines has been developed. By combining the exceptionally high reactivity of the Pd-PEPPSI-IPent(Cl) catalyst (PEPPSI=pyridine enhanced precatalyst preparation, sta...
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| Veröffentlicht in: | Angewandte Chemie International Edition 2015-08, Vol.54 (33), p.9507-9511 |
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| container_end_page | 9511 |
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| container_issue | 33 |
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| container_title | Angewandte Chemie International Edition |
| container_volume | 54 |
| creator | Sharif, Sepideh Rucker, Richard P Chandrasoma, Nalin Mitchell, David Rodriguez, Michael J Froese, Robert D J Organ, Michael G |
| description | A single set of reaction conditions for the palladium-catalyzed amination of a wide variety of (hetero)aryl halides using primary alkyl amines has been developed. By combining the exceptionally high reactivity of the Pd-PEPPSI-IPent(Cl) catalyst (PEPPSI=pyridine enhanced precatalyst preparation, stabilization, and initiation) with the soluble and nonaggressive sodium salt of BHT (BHT=2,6-di-tert-butyl-hydroxytoluene), both six- and five-membered (hetero)aryl halides undergo efficient and selective amination. |
| doi_str_mv | 10.1002/anie.201502822 |
| format | Article |
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| ispartof | Angewandte Chemie International Edition, 2015-08, Vol.54 (33), p.9507-9511 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Amination Amines - chemistry Butylated Hydroxytoluene - analogs & derivatives Butylated Hydroxytoluene - chemistry Catalysis Halogens - chemistry Hydrocarbons, Aromatic - chemistry Palladium - chemistry Pyridines - chemistry |
| title | Selective Monoarylation of Primary Amines Using the Pd-PEPPSI-IPent(Cl) Precatalyst |
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