Adenosines scavenged hydroxyl radicals and prevented posttraumatic epilepsy

Intracortical injection of iron ions has been used as a model of posttraumatic epilepsy. Oxidation of lipids in neural membranes by reactive oxygen species, especially hydroxyl radicals (OH), is involved in the mechanisms responsible for iron-induced seizures. We examined the scavenging effects of a...

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Veröffentlicht in:	Free radical biology & medicine 1995-10, Vol.19 (4), p.473-479
Hauptverfasser:	Yokoi, Isao, Toma, Junji, Liu, Jiankang, Kabuto, Hideaki, Mori, Akitane
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Chloroadenosine 2-Chloroadenosine - pharmacology 2-Chloroadenosine - therapeutic use Adenosine Adenosine - pharmacology Adenosine - therapeutic use Animals Chlorides Cyclic N-Oxides Electroencephalography Electron Spin Resonance Spectroscopy Epilepsy, Post-Traumatic - chemically induced Epilepsy, Post-Traumatic - prevention & control Experimental epilepsy Ferric Compounds Free Radical Scavengers Free Radicals Hydroxyl Radical - metabolism Hydroxyl radical scavenger Hypoxanthine Hypoxanthines - metabolism Iron-induced epilepsy Male Posttraumatic epilepsy Rats Rats, Sprague-Dawley Spin Labels Superoxides - metabolism Xanthine Oxidase - metabolism
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