Catalytic Asymmetric Hydrogenation of [alpha]-CF sub(3)- or [beta]-CF sub(3)-Substituted Acrylic Acids using Rhodium(I) Complexes with a Combination of Chiral and Achiral Ligands

Only the mixture works! Acrylic acid derivatives with CF sub(3) substituents in [alpha] or [beta]position were efficiently hydrogenated in the presence of a Rh super(I) complex with a chiral secondary phosphine oxide (SPO; see scheme) and an achiral Ph sub(3)P as ligands. The corresponding propanoic...

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Veröffentlicht in:	Angewandte Chemie International Edition 2013-12, Vol.52 (52), p.14191-14195
Hauptverfasser:	Dong, Kaiwu, Li, Yang, Wang, Zheng, Ding, Kuiling
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylic acid Asymmetry Catalysis Conversion Derivatives Hydrogenation Ligands Propanoic acid
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description	Only the mixture works! Acrylic acid derivatives with CF sub(3) substituents in [alpha] or [beta]position were efficiently hydrogenated in the presence of a Rh super(I) complex with a chiral secondary phosphine oxide (SPO; see scheme) and an achiral Ph sub(3)P as ligands. The corresponding propanoic acid derivatives were obtained with generally high conversion (>99%) and high enantioselectivity (92->99%).
doi_str_mv	10.1002/anie.201307903
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Acrylic acid derivatives with CF sub(3) substituents in [alpha] or [beta]position were efficiently hydrogenated in the presence of a Rh super(I) complex with a chiral secondary phosphine oxide (SPO; see scheme) and an achiral Ph sub(3)P as ligands. The corresponding propanoic acid derivatives were obtained with generally high conversion (>99%) and high enantioselectivity (92->99%).</abstract><doi>10.1002/anie.201307903</doi></addata></record>
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subjects	Acrylic acid Asymmetry Catalysis Conversion Derivatives Hydrogenation Ligands Propanoic acid
title	Catalytic Asymmetric Hydrogenation of [alpha]-CF sub(3)- or [beta]-CF sub(3)-Substituted Acrylic Acids using Rhodium(I) Complexes with a Combination of Chiral and Achiral Ligands
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