Solid-Phase Microextraction: A Complementary InVivo Sampling Method to Microdialysis

Solid-Phase Microextraction: A Complementary InVivo Sampling Method to Microdialysis

Two's compliment: Solid-phase microextraction (SPME) was validated against microdialysis (MD) in simultaneous targeted analysis of selected neurotransmitters in brain tissue. Complementary data was obtained from global brain profiling with both methods. MD extracts primarily polar species, and...

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Veröffentlicht in:Angewandte Chemie International Edition 2013-11, Vol.52 (46), p.12124-12126
Hauptverfasser: Cudjoe, Erasmus, Bojko, Barbara, deLannoy, Inés, Saldivia, Victor, Pawliszyn, Janusz
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Sprache:eng
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Brain
Lipids
Neurological diseases
Neurotransmitters
Profiling
Sampling methods
Semifabricated products
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container_end_page 12126
container_issue 46
container_start_page 12124
container_title Angewandte Chemie International Edition
container_volume 52
creator Cudjoe, Erasmus
Bojko, Barbara
deLannoy, Inés
Saldivia, Victor
Pawliszyn, Janusz
description Two's compliment: Solid-phase microextraction (SPME) was validated against microdialysis (MD) in simultaneous targeted analysis of selected neurotransmitters in brain tissue. Complementary data was obtained from global brain profiling with both methods. MD extracts primarily polar species, and SPME detects semi hydrophobic and hydrophobic compounds, including lipids related to neurodegenerative diseases. RT=retention time.
doi_str_mv 10.1002/anie.201304538
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subjects Brain
Lipids
Neurological diseases
Neurotransmitters
Profiling
Sampling methods
Semifabricated products
title Solid-Phase Microextraction: A Complementary InVivo Sampling Method to Microdialysis
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