Copper-Catalyzed Three-Component Oxytrifluoromethylation of Alkenes with Sodium Trifluoromethanesulfinate and Hydroxamic Acid

Radical paths: The title reaction of olefins with NaSO2CF3 and N‐hydroxy‐N‐phenylacetamide at room temperature is described for the first time (see scheme). This reaction provides a practical and convenient route to a series of trifluoromethylated alcohols bearing a wide range of functional groups....

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Veröffentlicht in:	Angewandte Chemie International Edition 2013-12, Vol.52 (52), p.14177-14180
Hauptverfasser:	Jiang, Xin-Yi, Qing, Feng-Ling
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohols Alkenes Alkenes - chemistry Bearing Catalysis copper Copper - chemistry fluorine Functional groups Hydroxamic Acids - chemistry Olefins Oxidation-Reduction radical chemistry Radicals Sodium Stereoisomerism synthetic methods
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Beschreibung
Zusammenfassung:	Radical paths: The title reaction of olefins with NaSO2CF3 and N‐hydroxy‐N‐phenylacetamide at room temperature is described for the first time (see scheme). This reaction provides a practical and convenient route to a series of trifluoromethylated alcohols bearing a wide range of functional groups.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.201307595