Sequestration of a [beta]-Hairpin for Control of [alpha]-Synuclein Aggregation

The misfolding and aggregation of the protein [alpha]-synuclein ([alpha]-syn), which results in the formation of amyloid fibrils, is involved in the pathogenesis of Parkinson's disease and other synucleinopathies. The emergence of amyloid toxicity is associated with the formation of partially f...

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Veröffentlicht in:	Angewandte Chemie International Edition 2014-04, Vol.53 (16), p.4227-4230
Hauptverfasser:	Mirecka, Ewa A, Shaykhalishahi, Hamed, Gauhar, Aziz, Akgul, Serife, Lecher, Justin, Willbold, Dieter, Stoldt, Matthias, Hoyer, Wolfgang
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Agglomeration Beta Binding Formations NMR spectroscopy Nucleation Protein folding Proteins Toxicity Wrapping
Online-Zugang:	Volltext
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