Synthesis of a heterogeneous artificial metallolipase with chimeric catalytic activity

A solid-phase strategy using lipase as a biomolecular scaffold to produce a large amount of Cu(2+)-metalloenzyme is proposed here. The application of this protocol on different 3D cavities of the enzyme allows creating a heterogeneous artificial metallolipase showing chimeric catalytic activity. The...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2015-06, Vol.51 (45), p.9324-9327
Hauptverfasser:	Filice, M, Romero, O, Gutiérrez-Fernández, J, de Las Rivas, B, Hermoso, J A, Palomo, J M
Format:	Artikel
Sprache:	eng
Schlagworte:	Cascades Catalysis Catalysts Catalytic activity Catalytic Domain Enzymes Holes Lipase - chemical synthesis Lipase - chemistry Metalloproteins - chemical synthesis Metalloproteins - chemistry Models, Molecular Strategy Synthesis Three dimensional
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!