Ruthenium red protects against glutamate-induced neuronal death in cerebellar culture

Intracytosplasmic concentration of calcium dramatically increases after glutamate exposure in cultured neurons. Here, we investigated the effects of glutamate (100 μM, 15 min) on the intramitochondrial calcium homeostasis using 45Ca as a radioactive tracer. Calcium content increased in both cytoplas...

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Veröffentlicht in:	Neuroscience letters 1995-12, Vol.201 (1), p.53-56
Hauptverfasser:	Dessi, Frédéric, Ben-Ari, Yezekiel, Charriaut-Marlangue, Christiane
Format:	Artikel
Sprache:	eng
Schlagworte:	Ageing, cell death Animals Biological and medical sciences Calcium - metabolism Calcium content Calcium Radioisotopes Cell Death - drug effects Cell physiology Cells, Cultured Cerebellum - cytology Cerebellum - drug effects Cytosol - drug effects Cytosol - metabolism Excitatory Amino Acid Antagonists - pharmacology Fundamental and applied biological sciences. Psychology Glutamate Glutamic Acid - toxicity Mitochondria - drug effects Mitochondria - metabolism Molecular and cellular biology Neuronal death Rats Ruthenium red Ruthenium Red - pharmacology
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