Bio-reduction of Redox-Sensitive Albumin Conjugates in FcRn-Expressing Cells
Disulfide‐containing IgG‐, Fc‐, or albumin‐based prodrugs that rely on FcRn‐trafficking by endothelial cells for prolonged circulation in the body might be hampered by premature bio‐reduction processes during FcRn‐mediated recycling events. A detailed bio‐reduction analysis of redox‐sensitive albumi...
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| Veröffentlicht in: | Angewandte Chemie 2014-08, Vol.126 (32), p.8532-8536 |
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| container_issue | 32 |
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| container_title | Angewandte Chemie |
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| creator | Brülisauer, Lorine Valentino, Gina Morinaga, Sakura Cam, Kübra Thostrup Bukrinski, Jens Gauthier, Marc A. Leroux, Jean-Christophe |
| description | Disulfide‐containing IgG‐, Fc‐, or albumin‐based prodrugs that rely on FcRn‐trafficking by endothelial cells for prolonged circulation in the body might be hampered by premature bio‐reduction processes during FcRn‐mediated recycling events. A detailed bio‐reduction analysis of redox‐sensitive albumin conjugates in two FcRn‐expressing cell lines has been performed. The obtained results indicate that the FcRn‐mediated recycling pathway is not (or is only poorly) bio‐reducing.
Disulfidhaltige IgG‐, Fc‐ oder Albumin‐basierte Prodrugs, die den FcRn‐Transportweg durch Endothelzellen nutzen, um länger im Körper zu verbleiben, könnten einer vorzeitigen biologischen Reduktion bei der FcRn‐Rezyklierung unterliegen. Eine entsprechende Analyse für redoxempfindliche Albuminkonjugate in zwei FcRn‐exprimierenden Zelllinien liefert neue Einblicke, um die Leistungsfähigkeit solcher Arzneistoffe zu steigern. |
| doi_str_mv | 10.1002/ange.201404238 |
| format | Article |
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Disulfidhaltige IgG‐, Fc‐ oder Albumin‐basierte Prodrugs, die den FcRn‐Transportweg durch Endothelzellen nutzen, um länger im Körper zu verbleiben, könnten einer vorzeitigen biologischen Reduktion bei der FcRn‐Rezyklierung unterliegen. Eine entsprechende Analyse für redoxempfindliche Albuminkonjugate in zwei FcRn‐exprimierenden Zelllinien liefert neue Einblicke, um die Leistungsfähigkeit solcher Arzneistoffe zu steigern.</description><identifier>ISSN: 0044-8249</identifier><identifier>EISSN: 1521-3757</identifier><identifier>DOI: 10.1002/ange.201404238</identifier><language>eng ; ger</language><publisher>Weinheim: WILEY-VCH Verlag</publisher><subject>Albumin ; Albumins ; Biotechnology ; Chemical compounds ; Chemistry ; Circulation ; Conjugates ; Disulfide ; Drugs ; Endothelial cells ; FcRn-Rezeptoren ; Pathways ; Recycling ; Reduktionen ; Wirkstofftransport</subject><ispartof>Angewandte Chemie, 2014-08, Vol.126 (32), p.8532-8536</ispartof><rights>2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2338-260807cc09ec6e81c75d777d3e4ea30ae1c2dbf8c70842e05c8f3e0e502ea553</citedby><cites>FETCH-LOGICAL-c2338-260807cc09ec6e81c75d777d3e4ea30ae1c2dbf8c70842e05c8f3e0e502ea553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fange.201404238$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fange.201404238$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids></links><search><creatorcontrib>Brülisauer, Lorine</creatorcontrib><creatorcontrib>Valentino, Gina</creatorcontrib><creatorcontrib>Morinaga, Sakura</creatorcontrib><creatorcontrib>Cam, Kübra</creatorcontrib><creatorcontrib>Thostrup Bukrinski, Jens</creatorcontrib><creatorcontrib>Gauthier, Marc A.</creatorcontrib><creatorcontrib>Leroux, Jean-Christophe</creatorcontrib><title>Bio-reduction of Redox-Sensitive Albumin Conjugates in FcRn-Expressing Cells</title><title>Angewandte Chemie</title><addtitle>Angew. Chem</addtitle><description>Disulfide‐containing IgG‐, Fc‐, or albumin‐based prodrugs that rely on FcRn‐trafficking by endothelial cells for prolonged circulation in the body might be hampered by premature bio‐reduction processes during FcRn‐mediated recycling events. A detailed bio‐reduction analysis of redox‐sensitive albumin conjugates in two FcRn‐expressing cell lines has been performed. The obtained results indicate that the FcRn‐mediated recycling pathway is not (or is only poorly) bio‐reducing.
Disulfidhaltige IgG‐, Fc‐ oder Albumin‐basierte Prodrugs, die den FcRn‐Transportweg durch Endothelzellen nutzen, um länger im Körper zu verbleiben, könnten einer vorzeitigen biologischen Reduktion bei der FcRn‐Rezyklierung unterliegen. Eine entsprechende Analyse für redoxempfindliche Albuminkonjugate in zwei FcRn‐exprimierenden Zelllinien liefert neue Einblicke, um die Leistungsfähigkeit solcher Arzneistoffe zu steigern.</description><subject>Albumin</subject><subject>Albumins</subject><subject>Biotechnology</subject><subject>Chemical compounds</subject><subject>Chemistry</subject><subject>Circulation</subject><subject>Conjugates</subject><subject>Disulfide</subject><subject>Drugs</subject><subject>Endothelial cells</subject><subject>FcRn-Rezeptoren</subject><subject>Pathways</subject><subject>Recycling</subject><subject>Reduktionen</subject><subject>Wirkstofftransport</subject><issn>0044-8249</issn><issn>1521-3757</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqFkU1rGzEQhkVpIK6Ta84LvfQidyStrN2jY_zRYpKQhPYoFO2skbuWXGk3tf9917iY0EtOw8DzDC_vEHLDYMQA-Ffj1zjiwHLIuSg-kAGTnFGhpPpIBgB5Tguel5fkU0obABhzVQ7I6tYFGrHqbOuCz0KdPWIV9vQJfXKte8Vs0rx0W-ezafCbbm1aTFm_ze2jp7P9LmJKzq-zKTZNuiIXtWkSXv-bQ_I8nz1Pl3R1v_g2nayo5UIUlI-hAGUtlGjHWDCrZKWUqgTmaAQYZJZXL3VhFRQ5R5C2qAUCSuBopBRD8uV0dhfD7w5Tq7cu2T6A8Ri6pJkCxoCpEnr083_oJnTR9-E0kxKE5FLynhqdKBtDShFrvYtua-JBM9DHbvWxW33uthfKk_DHNXh4h9aTu8XsrUtPrkst7s-uib_0WPXf0j_vFnr5gz_Mb5fftRR_AbcHi4g</recordid><startdate>20140804</startdate><enddate>20140804</enddate><creator>Brülisauer, Lorine</creator><creator>Valentino, Gina</creator><creator>Morinaga, Sakura</creator><creator>Cam, Kübra</creator><creator>Thostrup Bukrinski, Jens</creator><creator>Gauthier, Marc A.</creator><creator>Leroux, Jean-Christophe</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20140804</creationdate><title>Bio-reduction of Redox-Sensitive Albumin Conjugates in FcRn-Expressing Cells</title><author>Brülisauer, Lorine ; Valentino, Gina ; Morinaga, Sakura ; Cam, Kübra ; Thostrup Bukrinski, Jens ; Gauthier, Marc A. ; Leroux, Jean-Christophe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2338-260807cc09ec6e81c75d777d3e4ea30ae1c2dbf8c70842e05c8f3e0e502ea553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; ger</language><creationdate>2014</creationdate><topic>Albumin</topic><topic>Albumins</topic><topic>Biotechnology</topic><topic>Chemical compounds</topic><topic>Chemistry</topic><topic>Circulation</topic><topic>Conjugates</topic><topic>Disulfide</topic><topic>Drugs</topic><topic>Endothelial cells</topic><topic>FcRn-Rezeptoren</topic><topic>Pathways</topic><topic>Recycling</topic><topic>Reduktionen</topic><topic>Wirkstofftransport</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brülisauer, Lorine</creatorcontrib><creatorcontrib>Valentino, Gina</creatorcontrib><creatorcontrib>Morinaga, Sakura</creatorcontrib><creatorcontrib>Cam, Kübra</creatorcontrib><creatorcontrib>Thostrup Bukrinski, Jens</creatorcontrib><creatorcontrib>Gauthier, Marc A.</creatorcontrib><creatorcontrib>Leroux, Jean-Christophe</creatorcontrib><collection>Istex</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Angewandte Chemie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brülisauer, Lorine</au><au>Valentino, Gina</au><au>Morinaga, Sakura</au><au>Cam, Kübra</au><au>Thostrup Bukrinski, Jens</au><au>Gauthier, Marc A.</au><au>Leroux, Jean-Christophe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bio-reduction of Redox-Sensitive Albumin Conjugates in FcRn-Expressing Cells</atitle><jtitle>Angewandte Chemie</jtitle><addtitle>Angew. 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Disulfidhaltige IgG‐, Fc‐ oder Albumin‐basierte Prodrugs, die den FcRn‐Transportweg durch Endothelzellen nutzen, um länger im Körper zu verbleiben, könnten einer vorzeitigen biologischen Reduktion bei der FcRn‐Rezyklierung unterliegen. Eine entsprechende Analyse für redoxempfindliche Albuminkonjugate in zwei FcRn‐exprimierenden Zelllinien liefert neue Einblicke, um die Leistungsfähigkeit solcher Arzneistoffe zu steigern.</abstract><cop>Weinheim</cop><pub>WILEY-VCH Verlag</pub><doi>10.1002/ange.201404238</doi><tpages>5</tpages></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Albumin Albumins Biotechnology Chemical compounds Chemistry Circulation Conjugates Disulfide Drugs Endothelial cells FcRn-Rezeptoren Pathways Recycling Reduktionen Wirkstofftransport |
| title | Bio-reduction of Redox-Sensitive Albumin Conjugates in FcRn-Expressing Cells |
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