Al(OH) sub(3) facilitated synthesis of water-soluble, magnetic, radiolabelled and fluorescent hydroxyapatite nanoparticles

Al(OH) sub(3) facilitated synthesis of water-soluble, magnetic, radiolabelled and fluorescent hydroxyapatite nanoparticles

Magnetic and fluorescent hydroxyapatite nanoparticles were synthesised using Al(OH) sub(3)-stabilised MnFe sub(2)O sub(4) or Fe sub(3)O sub(4) nanoparticles as precursors. They were readily and efficiently radiolabelled with super(18)F. Bisphosphonate polyethylene glycol polymers were utilised to en...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2015-05, Vol.51 (45), p.9332-9335
Hauptverfasser: Cui, X, Green, MA, Blower, P J, Zhou, D, Yan, Y, Zhang, W, Djanashvili, K, Mathe, D, Veres, D S, Szigeti, K
Format: Artikel
Sprache:eng
Schlagworte:
Affinity
Hydroxyapatite
Labelling
Nanoparticles
Polyethylene glycol
Precursors
Stability
Synthesis
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Beschreibung
Zusammenfassung:Magnetic and fluorescent hydroxyapatite nanoparticles were synthesised using Al(OH) sub(3)-stabilised MnFe sub(2)O sub(4) or Fe sub(3)O sub(4) nanoparticles as precursors. They were readily and efficiently radiolabelled with super(18)F. Bisphosphonate polyethylene glycol polymers were utilised to endow the nanoparticles with excellent colloidal stability in water and to incorporate cyclam for high affinity labelling with super(64)Cu.
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc02259b