Fabrication of multi-well chips for spheroid cultures and implantable constructs through rapid prototyping techniques

ABSTRACT Three‐dimensional (3D) culture models are widely used in basic and translational research. In this study, to generate and culture multiple 3D cell spheroids, we exploited laser ablation and replica molding for the fabrication of polydimethylsiloxane (PDMS) multi‐well chips, which were valid...

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Veröffentlicht in:	Biotechnology and bioengineering 2015-07, Vol.112 (7), p.1457-1471
Hauptverfasser:	Lopa, Silvia, Piraino, Francesco, Kemp, Raymond J., Di Caro, Clelia, Lovati, Arianna B., Di Giancamillo, Alessia, Moroni, Lorenzo, Peretti, Giuseppe M., Rasponi, Marco, Moretti, Matteo
Format:	Artikel
Sprache:	eng
Schlagworte:	3D model Biotechnology Cell Count Cell Culture Techniques - instrumentation Cell Culture Techniques - methods cell spheroid Cells, Cultured Chip formation Chips Chondrocytes - physiology Collagen Construction Construction standards Culture Fabrication Gene expression Gene Expression Profiling Histology Humans implantable scaffold Rapid prototyping Silicone resins Spheroids Three dimensional imaging Time Factors tissue engineering Transplants & implants
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