The Molecular Machinery of Neurotransmitter Release (Nobel Lecture)
The most important property of synaptic transmission is its speed, which is crucial for the overall workings of the brain. In his Nobel Lecture, T. C. Südhof explains how the synaptic vesicle and the plasma membrane undergo rapid fusion during neurotransmitter release and how this process is spatial...
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| Veröffentlicht in: | Angewandte Chemie International Edition 2014-11, Vol.53 (47), p.12696-12717 |
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| container_title | Angewandte Chemie International Edition |
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| creator | Sudhof, Thomas C |
| description | The most important property of synaptic transmission is its speed, which is crucial for the overall workings of the brain. In his Nobel Lecture, T. C. Südhof explains how the synaptic vesicle and the plasma membrane undergo rapid fusion during neurotransmitter release and how this process is spatially organized, such that opening of Ca2+‐channels allows rapid translation of the entering Ca2+ signal into a fusion event. |
| doi_str_mv | 10.1002/anie.201406359 |
| format | Article |
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Chem. Int. Ed</addtitle><date>2014-11-17</date><risdate>2014</risdate><volume>53</volume><issue>47</issue><spage>12696</spage><epage>12717</epage><pages>12696-12717</pages><issn>1433-7851</issn><issn>1521-3773</issn><eissn>1521-3773</eissn><coden>ACIEAY</coden><abstract>The most important property of synaptic transmission is its speed, which is crucial for the overall workings of the brain. In his Nobel Lecture, T. C. Südhof explains how the synaptic vesicle and the plasma membrane undergo rapid fusion during neurotransmitter release and how this process is spatially organized, such that opening of Ca2+‐channels allows rapid translation of the entering Ca2+ signal into a fusion event.</abstract><cop>Weinheim</cop><pub>WILEY-VCH Verlag</pub><pmid>25339369</pmid><doi>10.1002/anie.201406359</doi><tpages>22</tpages><edition>International ed. in English</edition><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1433-7851 |
| ispartof | Angewandte Chemie International Edition, 2014-11, Vol.53 (47), p.12696-12717 |
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| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Brain Calcium - metabolism hormone secretion Humans intracellular signaling Lectures Membrane Fusion Membranes Molecular machinery Neuronal Plasticity Neurotransmitter Agents - metabolism Neurotransmitters Nobel Prize Signal processing SNARE Proteins - metabolism synaptic plasticity Synaptotagmins - metabolism Translations Vesicles vesicular transport |
| title | The Molecular Machinery of Neurotransmitter Release (Nobel Lecture) |
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