Reactive Oxygen Species-Responsive Protein Modification and Its Intracellular Delivery for Targeted Cancer Therapy

Herein we report a convenient chemical approach to reversibly modulate protein (RNase A) function and develop a protein that is responsive to reactive oxygen species (ROS) for targeted cancer therapy. The conjugation of RNase A with 4‐nitrophenyl 4‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl) benzy...

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Veröffentlicht in:	Angewandte Chemie International Edition 2014-12, Vol.53 (49), p.13444-13448
Hauptverfasser:	Wang, Ming, Sun, Shuo, Neufeld, Caleb I., Perez-Ramirez, Bernardo, Xu, Qiaobing
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzyl Compounds - chemistry Benzyl Compounds - metabolism Cancer Cancer therapies Carbonates Carbonates - chemistry Carbonates - metabolism Cell Line, Tumor Conjugation Cytotoxicity drug delivery Enzyme Therapy Humans Hydrogen peroxide Lysine Modulation nanoparticles Neoplasms - drug therapy Neoplasms - enzymology Neoplasms - metabolism Oxygen protein engineering Proteins Reactive Oxygen Species - metabolism Ribonuclease, Pancreatic - chemistry Ribonuclease, Pancreatic - metabolism Ribonuclease, Pancreatic - pharmacology Ribonuclease, Pancreatic - therapeutic use ROS-responsive targeted cancer therapy Therapy Tumors
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