General and Efficient Synthesis of Indoles through Triazene-Directed C-H Annulation

Unprotected indoles are prepared with the title method, which has a wide scope for alkynes. Excellent regioselectivity was accomplished for aryl–alkyl and alkyl–alkyl disubstituted acetylenes. This reaction features an unusual 1,2 rhodium migration and ring‐contraction‐triggered NN bond cleavage. I...

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Veröffentlicht in:	Angewandte Chemie International Edition 2013-05, Vol.52 (22), p.5795-5798
Hauptverfasser:	Wang, Chengming, Sun, Huan, Fang, Yan, Huang, Yong
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes Bonding Catalysis Chemical reactions Cleavage Conversion CH activation indole Indoles Indoles - chemical synthesis Migration Molecular Structure NN cleavage Rhodium Transition Elements - chemistry triazene Triazines - chemistry
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container_title	Angewandte Chemie International Edition
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creator	Wang, Chengming Sun, Huan Fang, Yan Huang, Yong
description	Unprotected indoles are prepared with the title method, which has a wide scope for alkynes. Excellent regioselectivity was accomplished for aryl–alkyl and alkyl–alkyl disubstituted acetylenes. This reaction features an unusual 1,2 rhodium migration and ring‐contraction‐triggered NN bond cleavage. It allows rapid conversion of the reaction products into several functional molecules.
doi_str_mv	10.1002/anie.201301742
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subjects	Alkynes Bonding Catalysis Chemical reactions Cleavage Conversion CH activation indole Indoles Indoles - chemical synthesis Migration Molecular Structure NN cleavage Rhodium Transition Elements - chemistry triazene Triazines - chemistry
title	General and Efficient Synthesis of Indoles through Triazene-Directed C-H Annulation
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