Top-Down Chemoenzymatic Approach to a High-Mannose-Type Glycan Library: Synthesis of a Common Precursor and Its Enzymatic Trimming

From the stacks: A novel method for construction of a high‐mannose‐type glycan library by systematic enzymatic trimming of a single synthetic Man9‐based precursor was developed. Efficient chemical synthesis of the tetradecasaccharide common precursor and orthogonal enzymatic trimming to obtain all M...

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