Improved DNA equilibrium binding affinity determinations of platinum(II) complexes using synchrotron radiation circular dichroism

The binding affinity of a series of square planar platinum(II) compounds of the type [Pt(A(L))(I(L))](2+), where A(L) is 1,2-diaminoethane and I(L) are 1,10-phenanthroline (phen), 4-methyl-1,10-phenanthroline (4Mephen), 5-methyl-1,10-phenanthroline (5Mephen), 4,7-dimethyl-1,10-phenanthroline (47Me2p...

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Veröffentlicht in:	Analyst (London) 2015-06, Vol.140 (12), p.4162-4169
Hauptverfasser:	Ang, Dale L, Jones, Nykola C, Stootman, Frank, Ghadirian, Bahman, Aldrich-Wright, Janice R
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Binding Circular Dichroism - instrumentation Circularity Constants Deoxyribonucleic acid Dichroism DNA - chemistry Mathematical analysis Organoplatinum Compounds - analysis Organoplatinum Compounds - chemistry Phenanthrolines - chemistry Synchrotron radiation Synchrotrons
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