Combating Multidrug-Resistant Bacteria: Current Strategies for the Discovery of Novel Antibacterials

The introduction of effective antibacterial therapies for infectious diseases in the mid‐20th century completely revolutionized clinical practices and helped to facilitate the development of modern medicine. Many potentially life‐threatening conditions became easily curable, greatly reducing the inc...

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Veröffentlicht in:	Angewandte Chemie International Edition 2013-10, Vol.52 (41), p.10706-10733
Hauptverfasser:	O'Connell, Kieron M. G., Hodgkinson, James T., Sore, Hannah F., Welch, Martin, Salmond, George P. C., Spring, David R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibiotics Antiinfectives and antibacterials antivirulence Bacteria Bacteria - chemistry Bacteria - drug effects Bacteria - genetics Bacterial infections Bacterial Infections - drug therapy Bacterial Infections - microbiology Bacteriocins - chemistry Bacteriocins - pharmacology Biological Products - chemistry Biological Products - pharmacology Complement Disabilities Drug Discovery - methods Drug Resistance, Multiple, Bacterial Drugs Humans medicinal chemistry Metagenome Molecular Sequence Data natural products Quorum Sensing - drug effects resistance Strategy Therapy
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