Catalytic Asymmetric Synthesis of Cyclic Ethers Containing an [alpha]-Tetrasubstituted Stereocenter

'Ether' furan or pyran: The exo-selective cyclization of enantioenriched allenols is accomplished with high chirality transfer using as little as 0.02mol% of a gold catalyst. The new method is effective in the synthesis of a wide range of enantioenriched cyclic ethers, which are prepared i...

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Veröffentlicht in:	Angewandte Chemie International Edition 2013-04, Vol.52 (18), p.4878-4882
Hauptverfasser:	Cox, Nick, Uehling, Mycah R, Haelsig, Karl T, Lalic, Gojko
Format:	Artikel
Sprache:	eng
Schlagworte:	Asymmetry Catalysis Catalysts Ethers Furans Gold Phosphates Synthesis
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description	'Ether' furan or pyran: The exo-selective cyclization of enantioenriched allenols is accomplished with high chirality transfer using as little as 0.02mol% of a gold catalyst. The new method is effective in the synthesis of a wide range of enantioenriched cyclic ethers, which are prepared in excellent yields in three steps from readily available propargylic phosphates.
doi_str_mv	10.1002/anie.201300174
format	Article
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subjects	Asymmetry Catalysis Catalysts Ethers Furans Gold Phosphates Synthesis
title	Catalytic Asymmetric Synthesis of Cyclic Ethers Containing an [alpha]-Tetrasubstituted Stereocenter
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