The Role of the Detergent Micelle in Preserving the Structure of Membrane Proteins in the Gas Phase

Despite the growing importance of the mass spectrometry of membrane proteins, it is not known how their transfer from solution into vacuum affects their stability and structure. To address this we have carried out a systematic investigation of ten membrane proteins solubilized in different detergent...

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Veröffentlicht in:	Angewandte Chemie International Edition 2015-04, Vol.54 (15), p.4577-4581
Hauptverfasser:	Reading, Eamonn, Liko, Idlir, Allison, Timothy M., Benesch, Justin L. P., Laganowsky, Arthur, Robinson, Carol V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aquaporins - chemistry Detergents Detergents - chemistry Escherichia coli - chemistry Escherichia coli Proteins - chemistry Gases - chemistry Humans Ion mobility ion mobility spectrometry Ionic mobility Ionization Ions Mass spectrometry Mass Spectrometry - methods membrane proteins Membrane Proteins - chemistry Membranes Micelles Models, Molecular Protein Conformation Protein Stability Proteins Scientific imaging Stability structural biology
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