Alternating Copolymerization by Nitroxide-Mediated Polymerization and Subsequent Orthogonal Functionalization
A novel method for the preparation of functionalized alternating copolymers is presented. Nitroxide‐mediated polymerization of hexafluoroisopropyl acrylate with 7‐octenyl vinyl ether provides the corresponding alternating polymer, which can be chemically modified using two orthogonal polymer‐analogo...
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| Veröffentlicht in: | Angewandte Chemie International Edition 2015-04, Vol.54 (17), p.5054-5059 |
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| creator | Tesch, Matthias Hepperle, Johannes A. M. Klaasen, Henning Letzel, Matthias Studer, Armido |
| description | A novel method for the preparation of functionalized alternating copolymers is presented. Nitroxide‐mediated polymerization of hexafluoroisopropyl acrylate with 7‐octenyl vinyl ether provides the corresponding alternating polymer, which can be chemically modified using two orthogonal polymer‐analogous reactions. A thiol–ene click reaction followed by amidation provides dual‐functionalized alternating copolymers. The potential of this method is illustrated by the preparation of a small library (15 examples) of functionalized alternating copolymers.
Alternating through double click: The title reaction of A with hexafluoroisopropyl acrylate (HFIPA) provides alternating polymer B, which can be chemically modified using two orthogonal polymer‐analogous reactions. With this method, a small library of fifteen functionalized alternating copolymers was prepared. |
| doi_str_mv | 10.1002/anie.201412206 |
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Alternating through double click: The title reaction of A with hexafluoroisopropyl acrylate (HFIPA) provides alternating polymer B, which can be chemically modified using two orthogonal polymer‐analogous reactions. With this method, a small library of fifteen functionalized alternating copolymers was prepared.</description><subject>Acrylates</subject><subject>Acrylates - chemistry</subject><subject>active esters</subject><subject>alternating polymerization</subject><subject>Click Chemistry</subject><subject>Copolymerization</subject><subject>Copolymers</subject><subject>Libraries</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Nitrogen Oxides - chemistry</subject><subject>nitroxide-mediated polymerization</subject><subject>orthogonal functionalization</subject><subject>Polymerization</subject><subject>Polymers - chemical synthesis</subject><subject>Polymers - chemistry</subject><subject>Sulfhydryl Compounds - chemistry</subject><subject>thiol-ene reactions</subject><subject>Vinyl Compounds - chemistry</subject><subject>Vinyl ethers</subject><issn>1433-7851</issn><issn>1521-3773</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0c9v0zAUB3ALgdgYXDmiSFy4pDzHsZ0cq27dJo0OCRjcLCd5GR6OXexErPvrSZRSAZedbNmf9_WPR8hrCgsKkL3XzuAiA5rTLAPxhBxTntGUScmejvOcsVQWnB6RFzHejb4oQDwnRxmXTIBkx6Rb2h6D071xt8nKb73ddRjMw7jgXVLtko3pg783DaYfsDG6xyb5-C_Srkk-DVXEnwO6PrkO_Xd_6522yXpw9US03duX5FmrbcRX-_GEfFmffV5dpFfX55er5VVa81yKtG1FpSXXkFdZCQJ4jbqkDTQUGWjkVVsXbQW6hIwj53Uh63ba44LlZSU4OyHv5txt8OOtYq86E2u0Vjv0Q1RUAgWWcw6PUyGZLGlZ5CN9-x-988P4d3ZWkDMoprMXs6qDjzFgq7bBdDrsFAU19UxNPVOHno0Fb_axQ9Vhc-B_mjSCcga_jMXdI3Fqubk8-zs8nWtN7PH-UKvDDzU9jKuvm3N1U5xSWq6_qRv2G8Uds9s</recordid><startdate>20150420</startdate><enddate>20150420</enddate><creator>Tesch, Matthias</creator><creator>Hepperle, Johannes A. 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| subjects | Acrylates Acrylates - chemistry active esters alternating polymerization Click Chemistry Copolymerization Copolymers Libraries Magnetic Resonance Spectroscopy Nitrogen Oxides - chemistry nitroxide-mediated polymerization orthogonal functionalization Polymerization Polymers - chemical synthesis Polymers - chemistry Sulfhydryl Compounds - chemistry thiol-ene reactions Vinyl Compounds - chemistry Vinyl ethers |
| title | Alternating Copolymerization by Nitroxide-Mediated Polymerization and Subsequent Orthogonal Functionalization |
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