Total Synthesis of MyceliothermophinsC, D, and E

The total synthesis of cytotoxic polyketides myceliothermophinsE (1), C (2), and D (3) through a cascade-based cyclization to form the trans-fused decalin system is described. The convergent synthesis delivered all three natural products through late-stage divergence and facilitated unambiguous C21...

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Veröffentlicht in:	Angewandte Chemie International Edition 2014-10, Vol.53 (41), p.10970-10974
Hauptverfasser:	Nicolaou, K C, Shi, Lei, Lu, Min, Pattanayak, Manas R, Shah, Akshay A, Ioannidou, Heraklidia A, Lamani, Manjunath
Format:	Artikel
Sprache:	eng
Schlagworte:	Cascades Crystallography Decalin Divergence Forges Natural products Precursors Synthesis X-rays
Online-Zugang:	Volltext
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