HI-6 Therapy and the acute phase response in the rat
The propensity of therapeutic doses of HI-6 (50 mg/kg) in combination with atropine sulphate (17 mg/kg), antidotes used to treat organophosphate poisoning, to induce the acute phase response (APR) in the laboratory rat was examined. A single intraperitoneal injection of HI-6, either alone or with at...
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| Veröffentlicht in: | Toxicology (Amsterdam) 1996-01, Vol.106 (1), p.11-17 |
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| creator | IVANOVIC-MATIC, S POZNANOVIC, G |
| description | The propensity of therapeutic doses of HI-6 (50 mg/kg) in combination with atropine sulphate (17 mg/kg), antidotes used to treat organophosphate poisoning, to induce the acute phase response (APR) in the laboratory rat was examined. A single intraperitoneal injection of HI-6, either alone or with atropine, caused a rapid doubling of the plasma coticosterone concentration. However, this increase was short-lived in comparison with corticosterone kinetics during the typical, turpentine-induced APR. The elevated glucocorticosteroid concentration did not affect acute phase protein (APP) gene transcription or mRNA and protein synthesis in the livers of oxime/atropine-treated rats. On the basis of these findings, we concluded that the administered doses of HI-6 and atropine did not induce the generalised, nonspecific APR. |
| doi_str_mv | 10.1016/0300-483X(95)03148-9 |
| format | Article |
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A single intraperitoneal injection of HI-6, either alone or with atropine, caused a rapid doubling of the plasma coticosterone concentration. However, this increase was short-lived in comparison with corticosterone kinetics during the typical, turpentine-induced APR. The elevated glucocorticosteroid concentration did not affect acute phase protein (APP) gene transcription or mRNA and protein synthesis in the livers of oxime/atropine-treated rats. On the basis of these findings, we concluded that the administered doses of HI-6 and atropine did not induce the generalised, nonspecific APR.</description><identifier>ISSN: 0300-483X</identifier><identifier>EISSN: 1879-3185</identifier><identifier>DOI: 10.1016/0300-483X(95)03148-9</identifier><identifier>PMID: 8571381</identifier><identifier>CODEN: TXICDD</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Acute phase response ; Acute-Phase Proteins - biosynthesis ; Acute-Phase Proteins - genetics ; Acute-Phase Reaction - chemically induced ; Animals ; Antidotes - administration & dosage ; Antidotes - therapeutic use ; Antidotes - toxicity ; Atropine ; Atropine - administration & dosage ; Atropine - therapeutic use ; Atropine - toxicity ; Biological and medical sciences ; Blood Proteins - biosynthesis ; Blotting, Northern ; Chemical and industrial products toxicology. Toxic occupational diseases ; Corticosterone - blood ; HI-6 ; Immunoelectrophoresis ; Injections, Intraperitoneal ; Liver - metabolism ; Male ; Medical sciences ; Oximes ; Pyridinium Compounds - administration & dosage ; Pyridinium Compounds - therapeutic use ; Pyridinium Compounds - toxicity ; Rats ; Rats, Wistar ; RNA, Messenger - analysis ; Soman - poisoning ; Toxicology ; Turpentine - toxicity ; Various organic compounds</subject><ispartof>Toxicology (Amsterdam), 1996-01, Vol.106 (1), p.11-17</ispartof><rights>1996</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-bca510f9372cb385221aca53814e75c5c2b2e26f93b61c80d660e98ce34856ba3</citedby><cites>FETCH-LOGICAL-c417t-bca510f9372cb385221aca53814e75c5c2b2e26f93b61c80d660e98ce34856ba3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0300483X95031489$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2962285$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8571381$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>IVANOVIC-MATIC, S</creatorcontrib><creatorcontrib>POZNANOVIC, G</creatorcontrib><title>HI-6 Therapy and the acute phase response in the rat</title><title>Toxicology (Amsterdam)</title><addtitle>Toxicology</addtitle><description>The propensity of therapeutic doses of HI-6 (50 mg/kg) in combination with atropine sulphate (17 mg/kg), antidotes used to treat organophosphate poisoning, to induce the acute phase response (APR) in the laboratory rat was examined. A single intraperitoneal injection of HI-6, either alone or with atropine, caused a rapid doubling of the plasma coticosterone concentration. However, this increase was short-lived in comparison with corticosterone kinetics during the typical, turpentine-induced APR. The elevated glucocorticosteroid concentration did not affect acute phase protein (APP) gene transcription or mRNA and protein synthesis in the livers of oxime/atropine-treated rats. On the basis of these findings, we concluded that the administered doses of HI-6 and atropine did not induce the generalised, nonspecific APR.</description><subject>Acute phase response</subject><subject>Acute-Phase Proteins - biosynthesis</subject><subject>Acute-Phase Proteins - genetics</subject><subject>Acute-Phase Reaction - chemically induced</subject><subject>Animals</subject><subject>Antidotes - administration & dosage</subject><subject>Antidotes - therapeutic use</subject><subject>Antidotes - toxicity</subject><subject>Atropine</subject><subject>Atropine - administration & dosage</subject><subject>Atropine - therapeutic use</subject><subject>Atropine - toxicity</subject><subject>Biological and medical sciences</subject><subject>Blood Proteins - biosynthesis</subject><subject>Blotting, Northern</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Corticosterone - blood</subject><subject>HI-6</subject><subject>Immunoelectrophoresis</subject><subject>Injections, Intraperitoneal</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Oximes</subject><subject>Pyridinium Compounds - administration & dosage</subject><subject>Pyridinium Compounds - therapeutic use</subject><subject>Pyridinium Compounds - toxicity</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>RNA, Messenger - analysis</subject><subject>Soman - poisoning</subject><subject>Toxicology</subject><subject>Turpentine - toxicity</subject><subject>Various organic compounds</subject><issn>0300-483X</issn><issn>1879-3185</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1Lw0AQhhdRaq3-A4UcRPQQ3e_sXgQpagsFLxW8LZvNhEbSJO4mQv-92w969DTLvM_MLA9C1wQ_EkzkE2YYp1yxr3stHjAjXKX6BI2JynTKiBKnaHxEztFFCN8YY8q4HKGREhlhiowRn81TmSxX4G23SWxTJP0KEuuGHpJuZQMkHkLXNvFRNbvM2_4SnZW2DnB1qBP0-fa6nM7Sxcf7fPqySB0nWZ_mzgqCS80y6nKmBKXExla8yyETTjiaU6AyArkkTuFCSgxaOWBcCZlbNkF3-72db38GCL1ZV8FBXdsG2iEYkuFoQpAI8j3ofBuCh9J0vlpbvzEEm60sszVhtiaMFmYny-g4dnPYP-RrKI5DBzsxvz3kNjhbl942rgpHjGpJqRIRe95jEF38VuBNcBU0DorKg-tN0Vb__-MPdq6DEQ</recordid><startdate>19960108</startdate><enddate>19960108</enddate><creator>IVANOVIC-MATIC, S</creator><creator>POZNANOVIC, G</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19960108</creationdate><title>HI-6 Therapy and the acute phase response in the rat</title><author>IVANOVIC-MATIC, S ; POZNANOVIC, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-bca510f9372cb385221aca53814e75c5c2b2e26f93b61c80d660e98ce34856ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Acute phase response</topic><topic>Acute-Phase Proteins - biosynthesis</topic><topic>Acute-Phase Proteins - genetics</topic><topic>Acute-Phase Reaction - chemically induced</topic><topic>Animals</topic><topic>Antidotes - administration & dosage</topic><topic>Antidotes - therapeutic use</topic><topic>Antidotes - toxicity</topic><topic>Atropine</topic><topic>Atropine - administration & dosage</topic><topic>Atropine - therapeutic use</topic><topic>Atropine - toxicity</topic><topic>Biological and medical sciences</topic><topic>Blood Proteins - biosynthesis</topic><topic>Blotting, Northern</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Corticosterone - blood</topic><topic>HI-6</topic><topic>Immunoelectrophoresis</topic><topic>Injections, Intraperitoneal</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Oximes</topic><topic>Pyridinium Compounds - administration & dosage</topic><topic>Pyridinium Compounds - therapeutic use</topic><topic>Pyridinium Compounds - toxicity</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>RNA, Messenger - analysis</topic><topic>Soman - poisoning</topic><topic>Toxicology</topic><topic>Turpentine - toxicity</topic><topic>Various organic compounds</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>IVANOVIC-MATIC, S</creatorcontrib><creatorcontrib>POZNANOVIC, G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Toxicology (Amsterdam)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>IVANOVIC-MATIC, S</au><au>POZNANOVIC, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HI-6 Therapy and the acute phase response in the rat</atitle><jtitle>Toxicology (Amsterdam)</jtitle><addtitle>Toxicology</addtitle><date>1996-01-08</date><risdate>1996</risdate><volume>106</volume><issue>1</issue><spage>11</spage><epage>17</epage><pages>11-17</pages><issn>0300-483X</issn><eissn>1879-3185</eissn><coden>TXICDD</coden><abstract>The propensity of therapeutic doses of HI-6 (50 mg/kg) in combination with atropine sulphate (17 mg/kg), antidotes used to treat organophosphate poisoning, to induce the acute phase response (APR) in the laboratory rat was examined. A single intraperitoneal injection of HI-6, either alone or with atropine, caused a rapid doubling of the plasma coticosterone concentration. However, this increase was short-lived in comparison with corticosterone kinetics during the typical, turpentine-induced APR. The elevated glucocorticosteroid concentration did not affect acute phase protein (APP) gene transcription or mRNA and protein synthesis in the livers of oxime/atropine-treated rats. On the basis of these findings, we concluded that the administered doses of HI-6 and atropine did not induce the generalised, nonspecific APR.</abstract><cop>Shannon</cop><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>8571381</pmid><doi>10.1016/0300-483X(95)03148-9</doi><tpages>7</tpages></addata></record> |
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| issn | 0300-483X 1879-3185 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acute phase response Acute-Phase Proteins - biosynthesis Acute-Phase Proteins - genetics Acute-Phase Reaction - chemically induced Animals Antidotes - administration & dosage Antidotes - therapeutic use Antidotes - toxicity Atropine Atropine - administration & dosage Atropine - therapeutic use Atropine - toxicity Biological and medical sciences Blood Proteins - biosynthesis Blotting, Northern Chemical and industrial products toxicology. Toxic occupational diseases Corticosterone - blood HI-6 Immunoelectrophoresis Injections, Intraperitoneal Liver - metabolism Male Medical sciences Oximes Pyridinium Compounds - administration & dosage Pyridinium Compounds - therapeutic use Pyridinium Compounds - toxicity Rats Rats, Wistar RNA, Messenger - analysis Soman - poisoning Toxicology Turpentine - toxicity Various organic compounds |
| title | HI-6 Therapy and the acute phase response in the rat |
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