Elucidating Diphosphoinositol Polyphosphate Function with Nonhydrolyzable Analogues

The diphosphoinositol polyphosphates (PP‐IPs) represent a novel class of high‐energy phosphate‐containing messengers which control a wide variety of cellular processes. It is thought that PP‐IPs exert their pleiotropic effects as allosteric regulators and through pyrophosphorylation of protein subst...

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Veröffentlicht in:	Angewandte Chemie 2014-07, Vol.126 (28), p.7320-7325
Hauptverfasser:	Wu, Mingxuan, Chong, Lucy S., Capolicchio, Samanta, Jessen, Henning J., Resnick, Adam C., Fiedler, Dorothea
Format:	Artikel
Sprache:	eng ; ger
Schlagworte:	Biochemistry Cellular Chemistry Degradation Diphosphoinositol-Polyphosphate Mechanistische Sonden Nichthydrolysierbare Analoga Phosphorylation Phosphorylierung Polyphosphates Protein Proteins Regulators Structural analysis Synthesis
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