Cobalt-Catalyzed C4-Selective Direct Alkylation of Pyridines

Cobalt-Catalyzed C4-Selective Direct Alkylation of Pyridines

How pyridine got its tail: A new catalyst for the atom‐economical C4‐selective direct alkylation of pyridines is described. A combination of CoBr2 and LiBEt3H catalyzes the reaction of pyridines with 1‐alkenes at 70 °C to give alkylation products with C4/C2 ratios of >20:1. Substrate/catalyst rat...

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Veröffentlicht in:Angewandte Chemie International Edition 2013-03, Vol.52 (11), p.3213-3216
Hauptverfasser: Andou, Takashi, Saga, Yutaka, Komai, Hirotomo, Matsunaga, Shigeki, Kanai, Motomu
Format: Artikel
Sprache:eng
Schlagworte:
Alkylation
atom economy
Catalysis
Catalysts
Cobalt - chemistry
heterocyclic compounds
Pyridines
Pyridines - chemistry
synthetic methods
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Zusammenfassung:How pyridine got its tail: A new catalyst for the atom‐economical C4‐selective direct alkylation of pyridines is described. A combination of CoBr2 and LiBEt3H catalyzes the reaction of pyridines with 1‐alkenes at 70 °C to give alkylation products with C4/C2 ratios of >20:1. Substrate/catalyst ratios of up to 4000, and a turnover number of 3440 were achieved.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201208666