Hydrogenative Dearomatization of Pyridine and an Asymmetric Aza-Friedel-Crafts Alkylation Sequence

Highly efficient synthesis of enantiomerically enriched substituted piperidines has been realized via chiral phosphoric acid catalyzed cascade hydrogenative dearomatization of substituted pyridines and aza‐Friedel‐Crafts reaction in good to excellent yields and enantioselectivity. The highly efficie...

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Veröffentlicht in:	Angewandte Chemie International Edition 2014-02, Vol.53 (8), p.2194-2197
Hauptverfasser:	Wang, Shuo-Guo, You, Shu-Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation asymmetric catalysis Asymmetry Aza Compounds - chemistry Cascades Catalysis Enantiomers Enrichment Friedel-Crafts reaction heterocycles Hydrogenation Metals - chemistry organocatalysis Oxidation-Reduction Pharmaceutical industry Phosphoric acid Phosphoric Acids Piperidine Pyridines Pyridines - chemistry reduction Stereoisomerism Substitutes Synthesis synthetic methods
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