Total Synthesis of (±)-HippolachninA

Total Synthesis of (±)-HippolachninA

The first total synthesis of the marine polyketide (±)-hippolachninA has been achieved in nine linear steps and an overall yield of 9%. Rapid access to the oxacyclobutapentalene core structure was secured by strategic application of an ene cyclization.

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Bibliographische Detailangaben
Veröffentlicht in:Angewandte Chemie International Edition 2015-02, Vol.54 (8), p.2378-2382
Hauptverfasser: Ruider, Stefan A, Sandmeier, Tobias, Carreira, Erick M
Format: Artikel
Sprache:eng
Schlagworte:
Marine
Synthesis
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Beschreibung
Zusammenfassung:The first total synthesis of the marine polyketide (±)-hippolachninA has been achieved in nine linear steps and an overall yield of 9%. Rapid access to the oxacyclobutapentalene core structure was secured by strategic application of an ene cyclization.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201410419