Ratiometric Fluorescence Imaging of Cellular Polarity: Decrease in Mitochondrial Polarity in Cancer Cells

Mitochondrial polarity strongly influences the intracellular transportation of proteins and interactions between biomacromolecules. The first fluorescent probe capable of the ratiometric imaging of mitochondrial polarity is reported. The probe, termed BOB, has two absorption maxima (λabs=426 and 561...

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Veröffentlicht in:	Angewandte Chemie International Edition 2015-02, Vol.54 (8), p.2510-2514
Hauptverfasser:	Jiang, Na, Fan, Jiangli, Xu, Feng, Peng, Xiaojun, Mu, Huiying, Wang, Jingyun, Xiong, Xiaoqing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzothiazoles - chemistry Benzothiazoles - metabolism Cancer cancer sensing Cell Line Cercopithecus aethiops COS Cells Coumarins - chemistry Coumarins - metabolism dyes Emission Fluorescence Fluorescent Dyes - chemistry Fluorescent Dyes - metabolism HeLa Cells Humans Imaging MCF-7 Cells Mice Microscopy, Confocal Mitochondria Mitochondria - metabolism Polarity ratiometric imaging Scripts Spectrometry, Fluorescence Transportation
Online-Zugang:	Volltext
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