Role of nitric oxide, adenosine, N-methyl- d-aspartate receptors, and neuronal activation in hypoxia-induced pial arteriolar dilation in rats

In this study, we tested the hypothesis that nitric oxide (NO) and adenosine (ADO) are the principal mediators of severe hypoxia-induced vasodilation. In addition, we examined whether activation of N-methyl- d-aspartate (NMDA) receptors and/or perivascular nerves plays a role. A closed cranial windo...

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Veröffentlicht in:	Brain research 1995-12, Vol.704 (1), p.61-70
Hauptverfasser:	Pelligrino, Dale A., Wang, Qiong, Koenig, Heidi M., Albrecht, Ronald F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Adenosine - physiology Animals Arginine - analogs & derivatives Arginine - pharmacology Arterioles - physiology Biological and medical sciences Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Dizocilpine Maleate - pharmacology Enzyme Inhibitors - pharmacology Excitatory Amino Acid Antagonists - pharmacology Fundamental and applied biological sciences. Psychology Hypercapnia Hypoxia Hypoxia, Brain - physiopathology Male N-Methyl-n-aspartate NG-Nitroarginine Methyl Ester Nitric oxide Nitric Oxide - physiology Nitric Oxide Synthase - antagonists & inhibitors Pia Mater - blood supply Pial arteriole Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - drug effects Receptors, N-Methyl-D-Aspartate - physiology Tetrodotoxin Tetrodotoxin - pharmacology Theophylline - analogs & derivatives Theophylline - pharmacology Vasodilation - physiology Vertebrates: nervous system and sense organs
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