Outcomes following renal transplantation in older renal transplant recipients: a single-center experience and “Croatian senior program”
Background/objective Outcomes of kidney transplantation in older patients have not, however, been fully defined. The aims of this study were to analyze the number of new end-stage renal disease (ESRD) patients ≥65 years of age who were managed with kidney transplantation and their survival through t...
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| Veröffentlicht in: | International urology and nephrology 2015-08, Vol.47 (8), p.1415-1422 |
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| creator | Mikolasevic, I. Racki, S. Spanjol, J. Zupan, Z. Jakopcic, I. Devcic, B. Orlic, L. |
| description | Background/objective
Outcomes of kidney transplantation in older patients have not, however, been fully defined. The aims of this study were to analyze the number of new end-stage renal disease (ESRD) patients ≥65 years of age who were managed with kidney transplantation and their survival through the study period. In addition, we have analyzed post-transplantation outcomes in younger and older renal transplant recipients (RTRs).
Methods
We have analyzed the mean age of 505 RTRs transplanted between January 1990 and December 2013. Older people were defined as aging 65 years or older. Of 505 RTRs, there were 73 (14.5 %) patients who were ≥65 years of age. Therefore, in further analysis, patients were divided into two subgroups: younger recipients (younger than 65 years) and older recipients (aging 65 years or older).
Results
In the period from 1990 to 2001, patients who were 65 years of age and older were only sporadically treated with kidney transplantation in Croatia. Since 2002, the number of patients older than 65 years undergoing renal transplantation has been increasing. The older recipients were more likely to receive organs from older donors (52.6 ± 16.8 vs. 45.8 ± 13.2;
p
= 0.0001). There were no significant differences due to HLA mismatch between the two groups of analyzed patients. There was no difference in the rates of DGF between the older and younger recipients. Older recipients were less likely than younger recipients to have acute rejection crisis during the first-ear after transplantation (16.4 vs. 34.7 %;
p
= 0.03). There were no significant differences due to readmission rates in the first-year post-transplantation between the two groups. There was no significant difference due to graft function and 1-year graft and patient's survival between young and older recipients. Serum creatinine values at 1 year were higher in older recipients who received kidneys from elderly donor.
Conclusion
Our experience supports the use of kidney transplantation in the population of older ESRD patients. We can increase patients and graft survivals in elderly individuals with careful pre-transplant evaluation and HLA matching. “Croatian senior program” that includes HLA matching represents a good approach for kidney transplantation in older ESRD patients. |
| doi_str_mv | 10.1007/s11255-015-1034-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1700335203</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3761992481</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-860067a6dc7ed8b696f2c25c8a9950fa73622c9c754a7546c46a036f10c481b83</originalsourceid><addsrcrecordid>eNp1kc-KFDEQxoMo7jj6AF4k4MVLtPK3O95k0FVY2IueQyZdPfTSnbRJN-pt776Cvtw-yWaYVUTxkITK96uvKD5CnnJ4yQGaV4VzoTUDrhkHqZi9RzZcN5IJ3ar7ZAMSOONGyDPyqJQrALAtwENyJgznhiu7Id8v1yWkCQvt0zimL0M80IzRj3TJPpZ59HHxy5AiHSJNY4f5H7l-hGEeMC7lNfW0VIsRWah1hfHrjLlqAamPHb25_rHLqRr6SAvGIWU653TIfrq5_vmYPOj9WPDJ3bsln969_bh7zy4uzz_s3lywoJRYWGsATONNFxrs2r2xphdB6NB6azX0vpFGiGBDo5WvxwRlPEjTcwiq5ftWbsmLk28d_XnFsrhpKAHHugymtTjeAEipRb225Plf6FVac92_UsZa1RqrjhQ_USGnUjL2bs7D5PM3x8Edk3KnpFxNyh2Tcrb2PLtzXvcTdr87fkVTAXECSpXiAfMfo__reguV_6HD</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1699486943</pqid></control><display><type>article</type><title>Outcomes following renal transplantation in older renal transplant recipients: a single-center experience and “Croatian senior program”</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Mikolasevic, I. ; Racki, S. ; Spanjol, J. ; Zupan, Z. ; Jakopcic, I. ; Devcic, B. ; Orlic, L.</creator><creatorcontrib>Mikolasevic, I. ; Racki, S. ; Spanjol, J. ; Zupan, Z. ; Jakopcic, I. ; Devcic, B. ; Orlic, L.</creatorcontrib><description>Background/objective
Outcomes of kidney transplantation in older patients have not, however, been fully defined. The aims of this study were to analyze the number of new end-stage renal disease (ESRD) patients ≥65 years of age who were managed with kidney transplantation and their survival through the study period. In addition, we have analyzed post-transplantation outcomes in younger and older renal transplant recipients (RTRs).
Methods
We have analyzed the mean age of 505 RTRs transplanted between January 1990 and December 2013. Older people were defined as aging 65 years or older. Of 505 RTRs, there were 73 (14.5 %) patients who were ≥65 years of age. Therefore, in further analysis, patients were divided into two subgroups: younger recipients (younger than 65 years) and older recipients (aging 65 years or older).
Results
In the period from 1990 to 2001, patients who were 65 years of age and older were only sporadically treated with kidney transplantation in Croatia. Since 2002, the number of patients older than 65 years undergoing renal transplantation has been increasing. The older recipients were more likely to receive organs from older donors (52.6 ± 16.8 vs. 45.8 ± 13.2;
p
= 0.0001). There were no significant differences due to HLA mismatch between the two groups of analyzed patients. There was no difference in the rates of DGF between the older and younger recipients. Older recipients were less likely than younger recipients to have acute rejection crisis during the first-ear after transplantation (16.4 vs. 34.7 %;
p
= 0.03). There were no significant differences due to readmission rates in the first-year post-transplantation between the two groups. There was no significant difference due to graft function and 1-year graft and patient's survival between young and older recipients. Serum creatinine values at 1 year were higher in older recipients who received kidneys from elderly donor.
Conclusion
Our experience supports the use of kidney transplantation in the population of older ESRD patients. We can increase patients and graft survivals in elderly individuals with careful pre-transplant evaluation and HLA matching. “Croatian senior program” that includes HLA matching represents a good approach for kidney transplantation in older ESRD patients.</description><identifier>ISSN: 0301-1623</identifier><identifier>EISSN: 1573-2584</identifier><identifier>DOI: 10.1007/s11255-015-1034-9</identifier><identifier>PMID: 26116149</identifier><identifier>CODEN: IURNAE</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Adult ; Age Factors ; Aged ; Croatia ; Female ; Follow-Up Studies ; Forecasting ; Graft Rejection - epidemiology ; Graft Survival ; Humans ; Incidence ; Kidney Failure, Chronic - mortality ; Kidney Failure, Chronic - surgery ; Kidney Transplantation ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Nephrology ; Nephrology - Original Paper ; Registries ; Retrospective Studies ; Survival Rate - trends ; Transplant Recipients ; Urology ; Young Adult</subject><ispartof>International urology and nephrology, 2015-08, Vol.47 (8), p.1415-1422</ispartof><rights>Springer Science+Business Media Dordrecht 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-860067a6dc7ed8b696f2c25c8a9950fa73622c9c754a7546c46a036f10c481b83</citedby><cites>FETCH-LOGICAL-c442t-860067a6dc7ed8b696f2c25c8a9950fa73622c9c754a7546c46a036f10c481b83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11255-015-1034-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11255-015-1034-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26116149$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mikolasevic, I.</creatorcontrib><creatorcontrib>Racki, S.</creatorcontrib><creatorcontrib>Spanjol, J.</creatorcontrib><creatorcontrib>Zupan, Z.</creatorcontrib><creatorcontrib>Jakopcic, I.</creatorcontrib><creatorcontrib>Devcic, B.</creatorcontrib><creatorcontrib>Orlic, L.</creatorcontrib><title>Outcomes following renal transplantation in older renal transplant recipients: a single-center experience and “Croatian senior program”</title><title>International urology and nephrology</title><addtitle>Int Urol Nephrol</addtitle><addtitle>Int Urol Nephrol</addtitle><description>Background/objective
Outcomes of kidney transplantation in older patients have not, however, been fully defined. The aims of this study were to analyze the number of new end-stage renal disease (ESRD) patients ≥65 years of age who were managed with kidney transplantation and their survival through the study period. In addition, we have analyzed post-transplantation outcomes in younger and older renal transplant recipients (RTRs).
Methods
We have analyzed the mean age of 505 RTRs transplanted between January 1990 and December 2013. Older people were defined as aging 65 years or older. Of 505 RTRs, there were 73 (14.5 %) patients who were ≥65 years of age. Therefore, in further analysis, patients were divided into two subgroups: younger recipients (younger than 65 years) and older recipients (aging 65 years or older).
Results
In the period from 1990 to 2001, patients who were 65 years of age and older were only sporadically treated with kidney transplantation in Croatia. Since 2002, the number of patients older than 65 years undergoing renal transplantation has been increasing. The older recipients were more likely to receive organs from older donors (52.6 ± 16.8 vs. 45.8 ± 13.2;
p
= 0.0001). There were no significant differences due to HLA mismatch between the two groups of analyzed patients. There was no difference in the rates of DGF between the older and younger recipients. Older recipients were less likely than younger recipients to have acute rejection crisis during the first-ear after transplantation (16.4 vs. 34.7 %;
p
= 0.03). There were no significant differences due to readmission rates in the first-year post-transplantation between the two groups. There was no significant difference due to graft function and 1-year graft and patient's survival between young and older recipients. Serum creatinine values at 1 year were higher in older recipients who received kidneys from elderly donor.
Conclusion
Our experience supports the use of kidney transplantation in the population of older ESRD patients. We can increase patients and graft survivals in elderly individuals with careful pre-transplant evaluation and HLA matching. “Croatian senior program” that includes HLA matching represents a good approach for kidney transplantation in older ESRD patients.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Croatia</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Forecasting</subject><subject>Graft Rejection - epidemiology</subject><subject>Graft Survival</subject><subject>Humans</subject><subject>Incidence</subject><subject>Kidney Failure, Chronic - mortality</subject><subject>Kidney Failure, Chronic - surgery</subject><subject>Kidney Transplantation</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Nephrology</subject><subject>Nephrology - Original Paper</subject><subject>Registries</subject><subject>Retrospective Studies</subject><subject>Survival Rate - trends</subject><subject>Transplant Recipients</subject><subject>Urology</subject><subject>Young Adult</subject><issn>0301-1623</issn><issn>1573-2584</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kc-KFDEQxoMo7jj6AF4k4MVLtPK3O95k0FVY2IueQyZdPfTSnbRJN-pt776Cvtw-yWaYVUTxkITK96uvKD5CnnJ4yQGaV4VzoTUDrhkHqZi9RzZcN5IJ3ar7ZAMSOONGyDPyqJQrALAtwENyJgznhiu7Id8v1yWkCQvt0zimL0M80IzRj3TJPpZ59HHxy5AiHSJNY4f5H7l-hGEeMC7lNfW0VIsRWah1hfHrjLlqAamPHb25_rHLqRr6SAvGIWU653TIfrq5_vmYPOj9WPDJ3bsln969_bh7zy4uzz_s3lywoJRYWGsATONNFxrs2r2xphdB6NB6azX0vpFGiGBDo5WvxwRlPEjTcwiq5ftWbsmLk28d_XnFsrhpKAHHugymtTjeAEipRb225Plf6FVac92_UsZa1RqrjhQ_USGnUjL2bs7D5PM3x8Edk3KnpFxNyh2Tcrb2PLtzXvcTdr87fkVTAXECSpXiAfMfo__reguV_6HD</recordid><startdate>20150801</startdate><enddate>20150801</enddate><creator>Mikolasevic, I.</creator><creator>Racki, S.</creator><creator>Spanjol, J.</creator><creator>Zupan, Z.</creator><creator>Jakopcic, I.</creator><creator>Devcic, B.</creator><creator>Orlic, L.</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20150801</creationdate><title>Outcomes following renal transplantation in older renal transplant recipients: a single-center experience and “Croatian senior program”</title><author>Mikolasevic, I. ; Racki, S. ; Spanjol, J. ; Zupan, Z. ; Jakopcic, I. ; Devcic, B. ; Orlic, L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-860067a6dc7ed8b696f2c25c8a9950fa73622c9c754a7546c46a036f10c481b83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Croatia</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Forecasting</topic><topic>Graft Rejection - epidemiology</topic><topic>Graft Survival</topic><topic>Humans</topic><topic>Incidence</topic><topic>Kidney Failure, Chronic - mortality</topic><topic>Kidney Failure, Chronic - surgery</topic><topic>Kidney Transplantation</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Nephrology</topic><topic>Nephrology - Original Paper</topic><topic>Registries</topic><topic>Retrospective Studies</topic><topic>Survival Rate - trends</topic><topic>Transplant Recipients</topic><topic>Urology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mikolasevic, I.</creatorcontrib><creatorcontrib>Racki, S.</creatorcontrib><creatorcontrib>Spanjol, J.</creatorcontrib><creatorcontrib>Zupan, Z.</creatorcontrib><creatorcontrib>Jakopcic, I.</creatorcontrib><creatorcontrib>Devcic, B.</creatorcontrib><creatorcontrib>Orlic, L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>International urology and nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mikolasevic, I.</au><au>Racki, S.</au><au>Spanjol, J.</au><au>Zupan, Z.</au><au>Jakopcic, I.</au><au>Devcic, B.</au><au>Orlic, L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Outcomes following renal transplantation in older renal transplant recipients: a single-center experience and “Croatian senior program”</atitle><jtitle>International urology and nephrology</jtitle><stitle>Int Urol Nephrol</stitle><addtitle>Int Urol Nephrol</addtitle><date>2015-08-01</date><risdate>2015</risdate><volume>47</volume><issue>8</issue><spage>1415</spage><epage>1422</epage><pages>1415-1422</pages><issn>0301-1623</issn><eissn>1573-2584</eissn><coden>IURNAE</coden><abstract>Background/objective
Outcomes of kidney transplantation in older patients have not, however, been fully defined. The aims of this study were to analyze the number of new end-stage renal disease (ESRD) patients ≥65 years of age who were managed with kidney transplantation and their survival through the study period. In addition, we have analyzed post-transplantation outcomes in younger and older renal transplant recipients (RTRs).
Methods
We have analyzed the mean age of 505 RTRs transplanted between January 1990 and December 2013. Older people were defined as aging 65 years or older. Of 505 RTRs, there were 73 (14.5 %) patients who were ≥65 years of age. Therefore, in further analysis, patients were divided into two subgroups: younger recipients (younger than 65 years) and older recipients (aging 65 years or older).
Results
In the period from 1990 to 2001, patients who were 65 years of age and older were only sporadically treated with kidney transplantation in Croatia. Since 2002, the number of patients older than 65 years undergoing renal transplantation has been increasing. The older recipients were more likely to receive organs from older donors (52.6 ± 16.8 vs. 45.8 ± 13.2;
p
= 0.0001). There were no significant differences due to HLA mismatch between the two groups of analyzed patients. There was no difference in the rates of DGF between the older and younger recipients. Older recipients were less likely than younger recipients to have acute rejection crisis during the first-ear after transplantation (16.4 vs. 34.7 %;
p
= 0.03). There were no significant differences due to readmission rates in the first-year post-transplantation between the two groups. There was no significant difference due to graft function and 1-year graft and patient's survival between young and older recipients. Serum creatinine values at 1 year were higher in older recipients who received kidneys from elderly donor.
Conclusion
Our experience supports the use of kidney transplantation in the population of older ESRD patients. We can increase patients and graft survivals in elderly individuals with careful pre-transplant evaluation and HLA matching. “Croatian senior program” that includes HLA matching represents a good approach for kidney transplantation in older ESRD patients.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>26116149</pmid><doi>10.1007/s11255-015-1034-9</doi><tpages>8</tpages></addata></record> |
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| issn | 0301-1623 1573-2584 |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Adult Age Factors Aged Croatia Female Follow-Up Studies Forecasting Graft Rejection - epidemiology Graft Survival Humans Incidence Kidney Failure, Chronic - mortality Kidney Failure, Chronic - surgery Kidney Transplantation Male Medicine Medicine & Public Health Middle Aged Nephrology Nephrology - Original Paper Registries Retrospective Studies Survival Rate - trends Transplant Recipients Urology Young Adult |
| title | Outcomes following renal transplantation in older renal transplant recipients: a single-center experience and “Croatian senior program” |
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