Exploratory study of pre-surgical medications with dienogest or leuprorelin in laparoscopic cystectomy of endometrial cysts
Aim The aim of this study was to compare the effects of pre‐surgical medication with dienogest or leuprorelin on post‐surgical ovarian function. Material and Methods We conducted an exploratory study in two centers in Japan that comprised 30 patients with ovarian endometrial cysts for whom surgical...
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| Veröffentlicht in: | The journal of obstetrics and gynaecology research 2015-08, Vol.41 (8), p.1234-1239 |
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| container_title | The journal of obstetrics and gynaecology research |
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| creator | Takenaka, Motoki Yano, Ryuichiro Hiraku, Yuka Shibata, Mayuko Hatano, Kayoko Yamamoto, Shiori Sato, Kazuki Yamamoto, Kazushige Morishige, Ken-ichiro |
| description | Aim
The aim of this study was to compare the effects of pre‐surgical medication with dienogest or leuprorelin on post‐surgical ovarian function.
Material and Methods
We conducted an exploratory study in two centers in Japan that comprised 30 patients with ovarian endometrial cysts for whom surgical excision was planned. Patients were enrolled and divided into pre‐surgical medication groups with dienogest or leuprorelin for 12 weeks. Thereafter, patients were treated by laparoscopic cystectomy. The primary outcome was ovarian function post‐surgery, as assessed by serum anti‐Müllerian hormone (AMH) level, antral follicle count (AFC) and resumption of menses. Secondary outcome was the effect of pre‐surgical medication, as assessed by the size of endometrial cysts and visual analog scale (VAS) score. Serum AMH, AFC, size of endometrial cysts, and VAS scores were measured at baseline (before medication), after medication (1 day before surgery), and at 4 and 12 weeks post‐surgery.
Results
Serum AMH levels did not change after pre‐surgical medication with either dienogest or leuprorelin. Although AMH decreased after surgery, it recovered by 12 weeks post‐surgery in both groups with no statistically significant difference. Mean AFC did not change after surgery in either group. Menses returned by 12 weeks post‐surgery in all patients except for those who were pregnant. The rate of reduction of endometrial cyst volume did not differ between the groups. Both dienogest and leuprorelin were associated with substantial reductions in VAS scores.
Conclusion
There were no statistically significant differences between pre‐surgical medication with dienogest and leuprorelin in post‐surgical ovarian function. Both medications were effective in reducing endometrial cyst volume and VAS score. |
| doi_str_mv | 10.1111/jog.12701 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1700333360</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1700333360</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4571-c7a47e3c6372f2dc619f69e64943e69ea6e569e416029649bed43e5b57e67b163</originalsourceid><addsrcrecordid>eNp1kEFP3DAQha2qVaG0h_6BysdyCNixY2-O7You0FU5lKpHy-tMtqZOHOxEEPHnGVjghmXpjTxvnsYfIZ85O-J4jq_i9oiXmvE3ZJ9LqQumK_UWayF5sWBa7ZEPOV8xxnXNF-_JXlkthBBysU_uTm6HEJMdY5ppHqdmprGlQ4IiT2nrnQ20gwZ19LHP9MaP_2jjoY9byCONiQaYhhQTBN9TvMEONsXs4uAddXMewY2xewyFvokdjMlj5kMnfyTvWhsyfHrSA_Lnx8nl8rRYX6zOlt_WhZOV5oXTVmoQTgldtmXjFK9bVYOStRSAhVVQoUiuWFnj6wYabFSbSoPSG67EAfm6y8VFryfc23Q-OwjB9hCnbLhmDHEIxdB6uLM6_ERO0Joh-c6m2XBmHlgbZG0eWaP3y1PstEFGL85nuGg43hlufID59SRzfrF6jix2Ex7B3b5M2PTfKC10Zf7-WplLppj--X1tfot7tg6aLA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1700333360</pqid></control><display><type>article</type><title>Exploratory study of pre-surgical medications with dienogest or leuprorelin in laparoscopic cystectomy of endometrial cysts</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Takenaka, Motoki ; Yano, Ryuichiro ; Hiraku, Yuka ; Shibata, Mayuko ; Hatano, Kayoko ; Yamamoto, Shiori ; Sato, Kazuki ; Yamamoto, Kazushige ; Morishige, Ken-ichiro</creator><creatorcontrib>Takenaka, Motoki ; Yano, Ryuichiro ; Hiraku, Yuka ; Shibata, Mayuko ; Hatano, Kayoko ; Yamamoto, Shiori ; Sato, Kazuki ; Yamamoto, Kazushige ; Morishige, Ken-ichiro</creatorcontrib><description>Aim
The aim of this study was to compare the effects of pre‐surgical medication with dienogest or leuprorelin on post‐surgical ovarian function.
Material and Methods
We conducted an exploratory study in two centers in Japan that comprised 30 patients with ovarian endometrial cysts for whom surgical excision was planned. Patients were enrolled and divided into pre‐surgical medication groups with dienogest or leuprorelin for 12 weeks. Thereafter, patients were treated by laparoscopic cystectomy. The primary outcome was ovarian function post‐surgery, as assessed by serum anti‐Müllerian hormone (AMH) level, antral follicle count (AFC) and resumption of menses. Secondary outcome was the effect of pre‐surgical medication, as assessed by the size of endometrial cysts and visual analog scale (VAS) score. Serum AMH, AFC, size of endometrial cysts, and VAS scores were measured at baseline (before medication), after medication (1 day before surgery), and at 4 and 12 weeks post‐surgery.
Results
Serum AMH levels did not change after pre‐surgical medication with either dienogest or leuprorelin. Although AMH decreased after surgery, it recovered by 12 weeks post‐surgery in both groups with no statistically significant difference. Mean AFC did not change after surgery in either group. Menses returned by 12 weeks post‐surgery in all patients except for those who were pregnant. The rate of reduction of endometrial cyst volume did not differ between the groups. Both dienogest and leuprorelin were associated with substantial reductions in VAS scores.
Conclusion
There were no statistically significant differences between pre‐surgical medication with dienogest and leuprorelin in post‐surgical ovarian function. Both medications were effective in reducing endometrial cyst volume and VAS score.</description><identifier>ISSN: 1341-8076</identifier><identifier>EISSN: 1447-0756</identifier><identifier>DOI: 10.1111/jog.12701</identifier><identifier>PMID: 25833348</identifier><language>eng</language><publisher>Australia: Blackwell Publishing Ltd</publisher><subject>Adult ; Anti-Mullerian Hormone - blood ; endometrial cyst ; Endometriosis - drug therapy ; Endometriosis - physiopathology ; Endometriosis - surgery ; Female ; Humans ; laparoscopic cystectomy ; Laparoscopy - methods ; Leuprolide - therapeutic use ; Nandrolone - analogs & derivatives ; Nandrolone - therapeutic use ; Ovarian Cysts - blood ; Ovarian Cysts - drug therapy ; Ovarian Cysts - physiopathology ; Ovarian Cysts - surgery ; ovarian function ; Ovary - pathology ; Ovary - physiopathology ; pre-surgical medication ; Visual Analog Scale</subject><ispartof>The journal of obstetrics and gynaecology research, 2015-08, Vol.41 (8), p.1234-1239</ispartof><rights>2015 The Authors. Journal of Obstetrics and Gynaecology Research © 2015 Japan Society of Obstetrics and Gynecology</rights><rights>2015 The Authors. Journal of Obstetrics and Gynaecology Research © 2015 Japan Society of Obstetrics and Gynecology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4571-c7a47e3c6372f2dc619f69e64943e69ea6e569e416029649bed43e5b57e67b163</citedby><cites>FETCH-LOGICAL-c4571-c7a47e3c6372f2dc619f69e64943e69ea6e569e416029649bed43e5b57e67b163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjog.12701$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjog.12701$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25833348$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takenaka, Motoki</creatorcontrib><creatorcontrib>Yano, Ryuichiro</creatorcontrib><creatorcontrib>Hiraku, Yuka</creatorcontrib><creatorcontrib>Shibata, Mayuko</creatorcontrib><creatorcontrib>Hatano, Kayoko</creatorcontrib><creatorcontrib>Yamamoto, Shiori</creatorcontrib><creatorcontrib>Sato, Kazuki</creatorcontrib><creatorcontrib>Yamamoto, Kazushige</creatorcontrib><creatorcontrib>Morishige, Ken-ichiro</creatorcontrib><title>Exploratory study of pre-surgical medications with dienogest or leuprorelin in laparoscopic cystectomy of endometrial cysts</title><title>The journal of obstetrics and gynaecology research</title><addtitle>J. Obstet. Gynaecol. Res</addtitle><description>Aim
The aim of this study was to compare the effects of pre‐surgical medication with dienogest or leuprorelin on post‐surgical ovarian function.
Material and Methods
We conducted an exploratory study in two centers in Japan that comprised 30 patients with ovarian endometrial cysts for whom surgical excision was planned. Patients were enrolled and divided into pre‐surgical medication groups with dienogest or leuprorelin for 12 weeks. Thereafter, patients were treated by laparoscopic cystectomy. The primary outcome was ovarian function post‐surgery, as assessed by serum anti‐Müllerian hormone (AMH) level, antral follicle count (AFC) and resumption of menses. Secondary outcome was the effect of pre‐surgical medication, as assessed by the size of endometrial cysts and visual analog scale (VAS) score. Serum AMH, AFC, size of endometrial cysts, and VAS scores were measured at baseline (before medication), after medication (1 day before surgery), and at 4 and 12 weeks post‐surgery.
Results
Serum AMH levels did not change after pre‐surgical medication with either dienogest or leuprorelin. Although AMH decreased after surgery, it recovered by 12 weeks post‐surgery in both groups with no statistically significant difference. Mean AFC did not change after surgery in either group. Menses returned by 12 weeks post‐surgery in all patients except for those who were pregnant. The rate of reduction of endometrial cyst volume did not differ between the groups. Both dienogest and leuprorelin were associated with substantial reductions in VAS scores.
Conclusion
There were no statistically significant differences between pre‐surgical medication with dienogest and leuprorelin in post‐surgical ovarian function. Both medications were effective in reducing endometrial cyst volume and VAS score.</description><subject>Adult</subject><subject>Anti-Mullerian Hormone - blood</subject><subject>endometrial cyst</subject><subject>Endometriosis - drug therapy</subject><subject>Endometriosis - physiopathology</subject><subject>Endometriosis - surgery</subject><subject>Female</subject><subject>Humans</subject><subject>laparoscopic cystectomy</subject><subject>Laparoscopy - methods</subject><subject>Leuprolide - therapeutic use</subject><subject>Nandrolone - analogs & derivatives</subject><subject>Nandrolone - therapeutic use</subject><subject>Ovarian Cysts - blood</subject><subject>Ovarian Cysts - drug therapy</subject><subject>Ovarian Cysts - physiopathology</subject><subject>Ovarian Cysts - surgery</subject><subject>ovarian function</subject><subject>Ovary - pathology</subject><subject>Ovary - physiopathology</subject><subject>pre-surgical medication</subject><subject>Visual Analog Scale</subject><issn>1341-8076</issn><issn>1447-0756</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEFP3DAQha2qVaG0h_6BysdyCNixY2-O7You0FU5lKpHy-tMtqZOHOxEEPHnGVjghmXpjTxvnsYfIZ85O-J4jq_i9oiXmvE3ZJ9LqQumK_UWayF5sWBa7ZEPOV8xxnXNF-_JXlkthBBysU_uTm6HEJMdY5ppHqdmprGlQ4IiT2nrnQ20gwZ19LHP9MaP_2jjoY9byCONiQaYhhQTBN9TvMEONsXs4uAddXMewY2xewyFvokdjMlj5kMnfyTvWhsyfHrSA_Lnx8nl8rRYX6zOlt_WhZOV5oXTVmoQTgldtmXjFK9bVYOStRSAhVVQoUiuWFnj6wYabFSbSoPSG67EAfm6y8VFryfc23Q-OwjB9hCnbLhmDHEIxdB6uLM6_ERO0Joh-c6m2XBmHlgbZG0eWaP3y1PstEFGL85nuGg43hlufID59SRzfrF6jix2Ex7B3b5M2PTfKC10Zf7-WplLppj--X1tfot7tg6aLA</recordid><startdate>201508</startdate><enddate>201508</enddate><creator>Takenaka, Motoki</creator><creator>Yano, Ryuichiro</creator><creator>Hiraku, Yuka</creator><creator>Shibata, Mayuko</creator><creator>Hatano, Kayoko</creator><creator>Yamamoto, Shiori</creator><creator>Sato, Kazuki</creator><creator>Yamamoto, Kazushige</creator><creator>Morishige, Ken-ichiro</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201508</creationdate><title>Exploratory study of pre-surgical medications with dienogest or leuprorelin in laparoscopic cystectomy of endometrial cysts</title><author>Takenaka, Motoki ; Yano, Ryuichiro ; Hiraku, Yuka ; Shibata, Mayuko ; Hatano, Kayoko ; Yamamoto, Shiori ; Sato, Kazuki ; Yamamoto, Kazushige ; Morishige, Ken-ichiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4571-c7a47e3c6372f2dc619f69e64943e69ea6e569e416029649bed43e5b57e67b163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Anti-Mullerian Hormone - blood</topic><topic>endometrial cyst</topic><topic>Endometriosis - drug therapy</topic><topic>Endometriosis - physiopathology</topic><topic>Endometriosis - surgery</topic><topic>Female</topic><topic>Humans</topic><topic>laparoscopic cystectomy</topic><topic>Laparoscopy - methods</topic><topic>Leuprolide - therapeutic use</topic><topic>Nandrolone - analogs & derivatives</topic><topic>Nandrolone - therapeutic use</topic><topic>Ovarian Cysts - blood</topic><topic>Ovarian Cysts - drug therapy</topic><topic>Ovarian Cysts - physiopathology</topic><topic>Ovarian Cysts - surgery</topic><topic>ovarian function</topic><topic>Ovary - pathology</topic><topic>Ovary - physiopathology</topic><topic>pre-surgical medication</topic><topic>Visual Analog Scale</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takenaka, Motoki</creatorcontrib><creatorcontrib>Yano, Ryuichiro</creatorcontrib><creatorcontrib>Hiraku, Yuka</creatorcontrib><creatorcontrib>Shibata, Mayuko</creatorcontrib><creatorcontrib>Hatano, Kayoko</creatorcontrib><creatorcontrib>Yamamoto, Shiori</creatorcontrib><creatorcontrib>Sato, Kazuki</creatorcontrib><creatorcontrib>Yamamoto, Kazushige</creatorcontrib><creatorcontrib>Morishige, Ken-ichiro</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of obstetrics and gynaecology research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takenaka, Motoki</au><au>Yano, Ryuichiro</au><au>Hiraku, Yuka</au><au>Shibata, Mayuko</au><au>Hatano, Kayoko</au><au>Yamamoto, Shiori</au><au>Sato, Kazuki</au><au>Yamamoto, Kazushige</au><au>Morishige, Ken-ichiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exploratory study of pre-surgical medications with dienogest or leuprorelin in laparoscopic cystectomy of endometrial cysts</atitle><jtitle>The journal of obstetrics and gynaecology research</jtitle><addtitle>J. Obstet. Gynaecol. Res</addtitle><date>2015-08</date><risdate>2015</risdate><volume>41</volume><issue>8</issue><spage>1234</spage><epage>1239</epage><pages>1234-1239</pages><issn>1341-8076</issn><eissn>1447-0756</eissn><abstract>Aim
The aim of this study was to compare the effects of pre‐surgical medication with dienogest or leuprorelin on post‐surgical ovarian function.
Material and Methods
We conducted an exploratory study in two centers in Japan that comprised 30 patients with ovarian endometrial cysts for whom surgical excision was planned. Patients were enrolled and divided into pre‐surgical medication groups with dienogest or leuprorelin for 12 weeks. Thereafter, patients were treated by laparoscopic cystectomy. The primary outcome was ovarian function post‐surgery, as assessed by serum anti‐Müllerian hormone (AMH) level, antral follicle count (AFC) and resumption of menses. Secondary outcome was the effect of pre‐surgical medication, as assessed by the size of endometrial cysts and visual analog scale (VAS) score. Serum AMH, AFC, size of endometrial cysts, and VAS scores were measured at baseline (before medication), after medication (1 day before surgery), and at 4 and 12 weeks post‐surgery.
Results
Serum AMH levels did not change after pre‐surgical medication with either dienogest or leuprorelin. Although AMH decreased after surgery, it recovered by 12 weeks post‐surgery in both groups with no statistically significant difference. Mean AFC did not change after surgery in either group. Menses returned by 12 weeks post‐surgery in all patients except for those who were pregnant. The rate of reduction of endometrial cyst volume did not differ between the groups. Both dienogest and leuprorelin were associated with substantial reductions in VAS scores.
Conclusion
There were no statistically significant differences between pre‐surgical medication with dienogest and leuprorelin in post‐surgical ovarian function. Both medications were effective in reducing endometrial cyst volume and VAS score.</abstract><cop>Australia</cop><pub>Blackwell Publishing Ltd</pub><pmid>25833348</pmid><doi>10.1111/jog.12701</doi><tpages>6</tpages></addata></record> |
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| ispartof | The journal of obstetrics and gynaecology research, 2015-08, Vol.41 (8), p.1234-1239 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Anti-Mullerian Hormone - blood endometrial cyst Endometriosis - drug therapy Endometriosis - physiopathology Endometriosis - surgery Female Humans laparoscopic cystectomy Laparoscopy - methods Leuprolide - therapeutic use Nandrolone - analogs & derivatives Nandrolone - therapeutic use Ovarian Cysts - blood Ovarian Cysts - drug therapy Ovarian Cysts - physiopathology Ovarian Cysts - surgery ovarian function Ovary - pathology Ovary - physiopathology pre-surgical medication Visual Analog Scale |
| title | Exploratory study of pre-surgical medications with dienogest or leuprorelin in laparoscopic cystectomy of endometrial cysts |
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