Maternal serum markers, characteristics and morbidly adherent placenta in women with previa
Objective: To examine associations with morbidly adherent placenta (MAP) among women with placenta previa. Study Design: Women with MAP (cases) and previa alone (controls) were identified from a cohort of 236 714 singleton pregnancies with both first and second trimester prenatal screening, and live...
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| Veröffentlicht in: | Journal of perinatology 2015-08, Vol.35 (8), p.570-574 |
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| container_title | Journal of perinatology |
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| creator | Lyell, D J Faucett, A M Baer, R J Blumenfeld, Y J Druzin, M L El-Sayed, Y Y Shaw, G M Currier, R J Jelliffe-Pawlowski, L L |
| description | Objective:
To examine associations with morbidly adherent placenta (MAP) among women with placenta previa.
Study Design:
Women with MAP (cases) and previa alone (controls) were identified from a cohort of 236 714 singleton pregnancies with both first and second trimester prenatal screening, and live birth and hospital discharge records; pregnancies with aneuploidies and neural tube or abdominal wall defects were excluded. Logistic binomial regression was used to compare cases with controls.
Result:
In all, 37 cases with MAP and 699 controls with previa alone were included. Risk for MAP was increased among multiparous women with pregnancy-associated plasma protein-A (PAPP-A) ⩾95th percentile (⩾2.63 multiple of the median (MoM); adjusted OR (aOR) 8.7, 95% confidence interval (CI) 2.8 to 27.4), maternal-serum alpha fetoprotein (MS-AFP) ⩾95th percentile (⩾1.79 MoM; aOR 2.8, 95% CI 1.0 to 8.0), and 1 and ⩾2 prior cesarean deliveries (CDs; aORs 4.4, 95% CI 1.5 to 13.6 and 18.4, 95% CI 5.9 to 57.5, respectively).
Conclusion:
Elevated PAPP-A, elevated MS-AFP and prior CDs are associated with MAP among women with previa. |
| doi_str_mv | 10.1038/jp.2015.40 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1700331715</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A425112430</galeid><sourcerecordid>A425112430</sourcerecordid><originalsourceid>FETCH-LOGICAL-c547t-85f8b1ea8e18e8cf6bd9d75fd2fcced03cb59d7d4cf834602b2cb55f35e1e1ec3</originalsourceid><addsrcrecordid>eNp9kl1rFTEQhoMo9li98QdIQBCp7jGfJ7uXpVgVKt7olRchm0y6Oe5u1mRX6b83y6naqshABmaeecObDEKPKdlSwutX-2nLCJVbQe6gDRVqV0kp-F20IUrwquZid4Qe5LwnZG2q--iIyYYppsgGfX5vZkij6XGGtAx4MOkLpPwS284kY0sv5DnYjM3o8BBTG1x_hY3rIME446k3tmSDw4i_xwHKGeYOTwm-BfMQ3fOmz_DoOh-jT-evP569rS4-vHl3dnpRWSnUXNXS1y0FUwOtobZ-17rGKekd89aCI9y2shScsH71QljLSkV6LoGWsPwYPT_oTil-XSDPegjZQt-bEeKSNVWEcE4VlQV9-ge6j8tqP2tWkB1teEP-R9Fd00jKiWp-U5emBx1GH-fyYuvV-lQwSSkTfNXa_oMq4WAINo7gQ6nfGnh2Y6AD089djv0yhzjm2-DJAbQp5pzA6ymF8n9XmhK9LobeT3pdDC1W-Mm1paUdwP1Cf25CAV4cgFxa4yWkG57_lvsB-F-_OQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1699513079</pqid></control><display><type>article</type><title>Maternal serum markers, characteristics and morbidly adherent placenta in women with previa</title><source>MEDLINE</source><source>SpringerLink Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Lyell, D J ; Faucett, A M ; Baer, R J ; Blumenfeld, Y J ; Druzin, M L ; El-Sayed, Y Y ; Shaw, G M ; Currier, R J ; Jelliffe-Pawlowski, L L</creator><creatorcontrib>Lyell, D J ; Faucett, A M ; Baer, R J ; Blumenfeld, Y J ; Druzin, M L ; El-Sayed, Y Y ; Shaw, G M ; Currier, R J ; Jelliffe-Pawlowski, L L</creatorcontrib><description>Objective:
To examine associations with morbidly adherent placenta (MAP) among women with placenta previa.
Study Design:
Women with MAP (cases) and previa alone (controls) were identified from a cohort of 236 714 singleton pregnancies with both first and second trimester prenatal screening, and live birth and hospital discharge records; pregnancies with aneuploidies and neural tube or abdominal wall defects were excluded. Logistic binomial regression was used to compare cases with controls.
Result:
In all, 37 cases with MAP and 699 controls with previa alone were included. Risk for MAP was increased among multiparous women with pregnancy-associated plasma protein-A (PAPP-A) ⩾95th percentile (⩾2.63 multiple of the median (MoM); adjusted OR (aOR) 8.7, 95% confidence interval (CI) 2.8 to 27.4), maternal-serum alpha fetoprotein (MS-AFP) ⩾95th percentile (⩾1.79 MoM; aOR 2.8, 95% CI 1.0 to 8.0), and 1 and ⩾2 prior cesarean deliveries (CDs; aORs 4.4, 95% CI 1.5 to 13.6 and 18.4, 95% CI 5.9 to 57.5, respectively).
Conclusion:
Elevated PAPP-A, elevated MS-AFP and prior CDs are associated with MAP among women with previa.</description><identifier>ISSN: 0743-8346</identifier><identifier>EISSN: 1476-5543</identifier><identifier>DOI: 10.1038/jp.2015.40</identifier><identifier>PMID: 25927270</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>692/308/1892 ; Abdominal wall ; Adolescent ; Adult ; alpha-Fetoproteins - analysis ; Biomarkers - blood ; California ; Cesarean Section - statistics & numerical data ; Confidence intervals ; Female ; Health risk assessment ; Humans ; Logistic Models ; Medicine ; Medicine & Public Health ; Neural tube ; original-article ; Pediatric Surgery ; Pediatrics ; Placenta ; Placenta Accreta - blood ; Placenta praevia ; Placenta Previa - blood ; Pregnancy ; Pregnancy Complications - blood ; Pregnancy Trimester, First ; Pregnancy Trimester, Second ; Pregnancy-Associated Plasma Protein-A - analysis ; Pregnant women ; Prenatal Diagnosis ; Statistical analysis ; Young Adult</subject><ispartof>Journal of perinatology, 2015-08, Vol.35 (8), p.570-574</ispartof><rights>Nature America, Inc. 2015</rights><rights>COPYRIGHT 2015 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Aug 2015</rights><rights>Nature America, Inc. 2015.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c547t-85f8b1ea8e18e8cf6bd9d75fd2fcced03cb59d7d4cf834602b2cb55f35e1e1ec3</citedby><cites>FETCH-LOGICAL-c547t-85f8b1ea8e18e8cf6bd9d75fd2fcced03cb59d7d4cf834602b2cb55f35e1e1ec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/jp.2015.40$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/jp.2015.40$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25927270$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lyell, D J</creatorcontrib><creatorcontrib>Faucett, A M</creatorcontrib><creatorcontrib>Baer, R J</creatorcontrib><creatorcontrib>Blumenfeld, Y J</creatorcontrib><creatorcontrib>Druzin, M L</creatorcontrib><creatorcontrib>El-Sayed, Y Y</creatorcontrib><creatorcontrib>Shaw, G M</creatorcontrib><creatorcontrib>Currier, R J</creatorcontrib><creatorcontrib>Jelliffe-Pawlowski, L L</creatorcontrib><title>Maternal serum markers, characteristics and morbidly adherent placenta in women with previa</title><title>Journal of perinatology</title><addtitle>J Perinatol</addtitle><addtitle>J Perinatol</addtitle><description>Objective:
To examine associations with morbidly adherent placenta (MAP) among women with placenta previa.
Study Design:
Women with MAP (cases) and previa alone (controls) were identified from a cohort of 236 714 singleton pregnancies with both first and second trimester prenatal screening, and live birth and hospital discharge records; pregnancies with aneuploidies and neural tube or abdominal wall defects were excluded. Logistic binomial regression was used to compare cases with controls.
Result:
In all, 37 cases with MAP and 699 controls with previa alone were included. Risk for MAP was increased among multiparous women with pregnancy-associated plasma protein-A (PAPP-A) ⩾95th percentile (⩾2.63 multiple of the median (MoM); adjusted OR (aOR) 8.7, 95% confidence interval (CI) 2.8 to 27.4), maternal-serum alpha fetoprotein (MS-AFP) ⩾95th percentile (⩾1.79 MoM; aOR 2.8, 95% CI 1.0 to 8.0), and 1 and ⩾2 prior cesarean deliveries (CDs; aORs 4.4, 95% CI 1.5 to 13.6 and 18.4, 95% CI 5.9 to 57.5, respectively).
Conclusion:
Elevated PAPP-A, elevated MS-AFP and prior CDs are associated with MAP among women with previa.</description><subject>692/308/1892</subject><subject>Abdominal wall</subject><subject>Adolescent</subject><subject>Adult</subject><subject>alpha-Fetoproteins - analysis</subject><subject>Biomarkers - blood</subject><subject>California</subject><subject>Cesarean Section - statistics & numerical data</subject><subject>Confidence intervals</subject><subject>Female</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neural tube</subject><subject>original-article</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Placenta</subject><subject>Placenta Accreta - blood</subject><subject>Placenta praevia</subject><subject>Placenta Previa - blood</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - blood</subject><subject>Pregnancy Trimester, First</subject><subject>Pregnancy Trimester, Second</subject><subject>Pregnancy-Associated Plasma Protein-A - analysis</subject><subject>Pregnant women</subject><subject>Prenatal Diagnosis</subject><subject>Statistical analysis</subject><subject>Young Adult</subject><issn>0743-8346</issn><issn>1476-5543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kl1rFTEQhoMo9li98QdIQBCp7jGfJ7uXpVgVKt7olRchm0y6Oe5u1mRX6b83y6naqshABmaeecObDEKPKdlSwutX-2nLCJVbQe6gDRVqV0kp-F20IUrwquZid4Qe5LwnZG2q--iIyYYppsgGfX5vZkij6XGGtAx4MOkLpPwS284kY0sv5DnYjM3o8BBTG1x_hY3rIME446k3tmSDw4i_xwHKGeYOTwm-BfMQ3fOmz_DoOh-jT-evP569rS4-vHl3dnpRWSnUXNXS1y0FUwOtobZ-17rGKekd89aCI9y2shScsH71QljLSkV6LoGWsPwYPT_oTil-XSDPegjZQt-bEeKSNVWEcE4VlQV9-ge6j8tqP2tWkB1teEP-R9Fd00jKiWp-U5emBx1GH-fyYuvV-lQwSSkTfNXa_oMq4WAINo7gQ6nfGnh2Y6AD089djv0yhzjm2-DJAbQp5pzA6ymF8n9XmhK9LobeT3pdDC1W-Mm1paUdwP1Cf25CAV4cgFxa4yWkG57_lvsB-F-_OQ</recordid><startdate>20150801</startdate><enddate>20150801</enddate><creator>Lyell, D J</creator><creator>Faucett, A M</creator><creator>Baer, R J</creator><creator>Blumenfeld, Y J</creator><creator>Druzin, M L</creator><creator>El-Sayed, Y Y</creator><creator>Shaw, G M</creator><creator>Currier, R J</creator><creator>Jelliffe-Pawlowski, L L</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7RV</scope><scope>7T5</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20150801</creationdate><title>Maternal serum markers, characteristics and morbidly adherent placenta in women with previa</title><author>Lyell, D J ; Faucett, A M ; Baer, R J ; Blumenfeld, Y J ; Druzin, M L ; El-Sayed, Y Y ; Shaw, G M ; Currier, R J ; Jelliffe-Pawlowski, L L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c547t-85f8b1ea8e18e8cf6bd9d75fd2fcced03cb59d7d4cf834602b2cb55f35e1e1ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>692/308/1892</topic><topic>Abdominal wall</topic><topic>Adolescent</topic><topic>Adult</topic><topic>alpha-Fetoproteins - analysis</topic><topic>Biomarkers - blood</topic><topic>California</topic><topic>Cesarean Section - statistics & numerical data</topic><topic>Confidence intervals</topic><topic>Female</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neural tube</topic><topic>original-article</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Placenta</topic><topic>Placenta Accreta - blood</topic><topic>Placenta praevia</topic><topic>Placenta Previa - blood</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - blood</topic><topic>Pregnancy Trimester, First</topic><topic>Pregnancy Trimester, Second</topic><topic>Pregnancy-Associated Plasma Protein-A - analysis</topic><topic>Pregnant women</topic><topic>Prenatal Diagnosis</topic><topic>Statistical analysis</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lyell, D J</creatorcontrib><creatorcontrib>Faucett, A M</creatorcontrib><creatorcontrib>Baer, R J</creatorcontrib><creatorcontrib>Blumenfeld, Y J</creatorcontrib><creatorcontrib>Druzin, M L</creatorcontrib><creatorcontrib>El-Sayed, Y Y</creatorcontrib><creatorcontrib>Shaw, G M</creatorcontrib><creatorcontrib>Currier, R J</creatorcontrib><creatorcontrib>Jelliffe-Pawlowski, L L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of perinatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lyell, D J</au><au>Faucett, A M</au><au>Baer, R J</au><au>Blumenfeld, Y J</au><au>Druzin, M L</au><au>El-Sayed, Y Y</au><au>Shaw, G M</au><au>Currier, R J</au><au>Jelliffe-Pawlowski, L L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal serum markers, characteristics and morbidly adherent placenta in women with previa</atitle><jtitle>Journal of perinatology</jtitle><stitle>J Perinatol</stitle><addtitle>J Perinatol</addtitle><date>2015-08-01</date><risdate>2015</risdate><volume>35</volume><issue>8</issue><spage>570</spage><epage>574</epage><pages>570-574</pages><issn>0743-8346</issn><eissn>1476-5543</eissn><abstract>Objective:
To examine associations with morbidly adherent placenta (MAP) among women with placenta previa.
Study Design:
Women with MAP (cases) and previa alone (controls) were identified from a cohort of 236 714 singleton pregnancies with both first and second trimester prenatal screening, and live birth and hospital discharge records; pregnancies with aneuploidies and neural tube or abdominal wall defects were excluded. Logistic binomial regression was used to compare cases with controls.
Result:
In all, 37 cases with MAP and 699 controls with previa alone were included. Risk for MAP was increased among multiparous women with pregnancy-associated plasma protein-A (PAPP-A) ⩾95th percentile (⩾2.63 multiple of the median (MoM); adjusted OR (aOR) 8.7, 95% confidence interval (CI) 2.8 to 27.4), maternal-serum alpha fetoprotein (MS-AFP) ⩾95th percentile (⩾1.79 MoM; aOR 2.8, 95% CI 1.0 to 8.0), and 1 and ⩾2 prior cesarean deliveries (CDs; aORs 4.4, 95% CI 1.5 to 13.6 and 18.4, 95% CI 5.9 to 57.5, respectively).
Conclusion:
Elevated PAPP-A, elevated MS-AFP and prior CDs are associated with MAP among women with previa.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>25927270</pmid><doi>10.1038/jp.2015.40</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0743-8346 |
| ispartof | Journal of perinatology, 2015-08, Vol.35 (8), p.570-574 |
| issn | 0743-8346 1476-5543 |
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| source | MEDLINE; SpringerLink Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | 692/308/1892 Abdominal wall Adolescent Adult alpha-Fetoproteins - analysis Biomarkers - blood California Cesarean Section - statistics & numerical data Confidence intervals Female Health risk assessment Humans Logistic Models Medicine Medicine & Public Health Neural tube original-article Pediatric Surgery Pediatrics Placenta Placenta Accreta - blood Placenta praevia Placenta Previa - blood Pregnancy Pregnancy Complications - blood Pregnancy Trimester, First Pregnancy Trimester, Second Pregnancy-Associated Plasma Protein-A - analysis Pregnant women Prenatal Diagnosis Statistical analysis Young Adult |
| title | Maternal serum markers, characteristics and morbidly adherent placenta in women with previa |
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