Determination of dopamine concentrations in brain extracellular fluid using microdialysis with short sampling intervals, analyzed by ultra high performance liquid chromatography tandem mass spectrometry

An increase in striatal dopamine is considered essential for the rewarding and reinforcing effects of drugs of abuse. We have developed and validated an ultra high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) method for the analysis of dopamine in rat brain extracellular...

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Veröffentlicht in:	Journal of pharmacological and toxicological methods 2015-07, Vol.74, p.75-79
Hauptverfasser:	Gottås, A., Ripel, Å., Boix, F., Vindenes, V., Mørland, J., Øiestad, E.L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - metabolism Chromatography, High Pressure Liquid - methods Dopamine Dopamine - metabolism Extracellular Fluid - metabolism Heroin Heroin - metabolism Limit of Detection Microdialysis Microdialysis - methods Rats Reproducibility of Results Tandem Mass Spectrometry - methods UHPLC-MS/MS Ultra high performance liquid chromatography tandem mass spectrometry
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