Developmentally Regulated Sensitivity of Trypanosoma brucei brucei to the Cytotoxic Effects of Human High-Density Lipoprotein

The bloodstream developmental stages of the protozoan parasite Trypanosoma brucei brucei are lysed by normal human serum. The cytotoxic factor is a minor sub-class of human high-density lipoprotein termed trypanosome lyric factor (TLF). T. b. brucei rapidly develops resistance to TLF when incubated...

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Veröffentlicht in:	Experimental parasitology 1995-09, Vol.81 (2), p.216-226
Hauptverfasser:	Moore, D.R., Smith, A., Hager, K.M., Waldon, R., Esko, J.D., Hajduk, S.L.
Format:	Artikel
Sprache:	eng
Schlagworte:	ANIMAL DEVELOPMENTAL STAGES Animals Biological and medical sciences Biological Transport BLOOD SERUM Cell Differentiation CYTOTOXICITY Cytotoxins Drug Resistance Endocytosis ETAPAS DEL DESARROLLO ANIMAL Experimental protozoal diseases and models Female Fluorescent Antibody Technique GENERO HUMANO GENRE HUMAIN Humans Infectious diseases LIPOPROTEINAS LIPOPROTEINE LIPOPROTEINS Lipoproteins, HDL - metabolism Lipoproteins, HDL - pharmacology MANKIND Medical sciences Parasitic diseases PROCYCLIC TRYPANOSOMES Protein Binding Protozoal diseases Protozoan Proteins - biosynthesis Rats RESISTANCE SERUM SANGUIN STADE DE DEVELOPPEMENT ANIMAL SUERO SANGUINEO SUSCEPTIBILITY TOXICIDAD TOXICITE TOXICITY Toxicity Tests Trypanocidal Agents - blood Trypanocidal Agents - metabolism Trypanocidal Agents - pharmacology TRYPANOSOMA BRUCEI Trypanosoma brucei brucei Trypanosoma brucei brucei - drug effects Trypanosoma brucei brucei - growth & development Trypanosoma brucei brucei - ultrastructure TRYPANOSOME LYTIC FACTOR Variant Surface Glycoproteins, Trypanosoma - analysis
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