A Mutant of Melanoma Growth Stimulating Activity Does Not Activate Neutrophils but Blocks Erythrocyte Invasion by Malaria

Alanine scanning mutagenesis of the charged amino acids of melanoma growth stimulating activity (MGSA) was used to identify specific residues that are involved in binding to the human erythrocyte Duffy antigen/chemokine receptor (DARC) and to the type B interleukin-8 receptor (IL-8RB) on neutrophils...

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Veröffentlicht in:	The Journal of biological chemistry 1995-05, Vol.270 (19), p.11472-11476
Hauptverfasser:	Hesselgesser, Joseph, Chitnis, Chetan E., Miller, Louis H., Yansura, Daniel G., Simmons, Laura C., Fairbrother, Wayne J., Kotts, Claire, Wirth, Cindy, Gillece-Castro, Beth L., Horuk, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Amino Acid Sequence Animals Cell Line Chemokine CXCL1 Chemokines, CXC Chemotactic Factors - chemistry Chemotactic Factors - metabolism Chemotactic Factors - pharmacology Cloning, Molecular Conserved Sequence Duffy Blood-Group System - metabolism Erythrocytes - drug effects Erythrocytes - parasitology Escherichia coli Growth Substances - chemistry Growth Substances - metabolism Growth Substances - pharmacology Humans Intercellular Signaling Peptides and Proteins Kidney Kinetics Malaria - blood Models, Molecular Molecular Sequence Data Mutagenesis, Site-Directed Neoplasm Proteins - metabolism Neoplasm Proteins - pharmacology Neutrophil Activation Neutrophils - drug effects Neutrophils - physiology Plasmodium falciparum Plasmodium knowlesi - drug effects Plasmodium knowlesi - pathogenicity Protein Conformation Receptors, Cytokine - metabolism Recombinant Proteins - chemistry Recombinant Proteins - metabolism Recombinant Proteins - pharmacology Sequence Homology, Amino Acid Transfection
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