Association of p53 and mdm2 in the development and progression of non-small cell lung cancer

MDM2 protein is an important regulator of the p53 pathway and has a large effect on the anti-tumorigenic activity of the p53. Presently, we aimed to analyze the possible association of p53 and mdm2 in the development and progression of non-small cell lung cancer. In addition, impact of an important...

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Veröffentlicht in:	Tumor biology 2015-07, Vol.36 (7), p.5425-5432
Hauptverfasser:	Javid, Jamsheed, Mir, Rashid, Julka, P. K., Ray, P. C., Saxena, Alpana
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Analysis Biomedical and Life Sciences Biomedicine Cancer Research Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - pathology Case-Control Studies Disease Progression Female Gene expression Gene Expression Regulation, Neoplastic Genetic Association Studies Humans Lung cancer Male Middle Aged Polymorphism Polymorphism, Single Nucleotide Promoter Regions, Genetic Proteins Proto-Oncogene Proteins c-mdm2 - biosynthesis Proto-Oncogene Proteins c-mdm2 - genetics Research Article Studies Tumor Suppressor Protein p53 - biosynthesis Tumor Suppressor Protein p53 - genetics
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