Poststroke Epilepsy Is Associated With a High Mortality After a Stroke at Young Age: Follow-Up of Transient Ischemic Attack and Stroke Patients and Unelucidated Risk Factor Evaluation Study
BACKGROUND AND PURPOSE—Poststroke epilepsy is a common complication after a young stroke. We investigated the association between poststroke epilepsy and mortality. METHODS—We performed a prospective cohort study among 631 patients with a first-ever transient ischemic attack or ischemic stroke, aged...
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| Veröffentlicht in: | Stroke (1970) 2015-08, Vol.46 (8), p.2309-2311 |
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| container_title | Stroke (1970) |
| container_volume | 46 |
| creator | Arntz, Renate M Rutten-Jacobs, Loes C.A Maaijwee, Noortje A.M Schoonderwaldt, Hennie C Dorresteijn, Lucille D.A van Dijk, Ewoud J de Leeuw, Frank-Erik |
| description | BACKGROUND AND PURPOSE—Poststroke epilepsy is a common complication after a young stroke. We investigated the association between poststroke epilepsy and mortality.
METHODS—We performed a prospective cohort study among 631 patients with a first-ever transient ischemic attack or ischemic stroke, aged 18 to 50 years. Survival analysis and Cox proportional hazard analysis were used to estimate cumulative mortality and hazard ratios for patients with and without epilepsy.
RESULTS—After mean follow-up of 12.5 years (SD 8.6), 76 (12.0%) developed poststroke epilepsy. Case fatality was 27.4% for patients with poststroke epilepsy and 2.1% for those without. Poststroke epilepsy was associated with 30-day mortality (hazard ratio, 4.8; 95% confidence interval, 1.7–14.0) and long-term mortality (hazard ratio, 1.8; 95% confidence interval, 1.2–2.9).
CONCLUSIONS—Epilepsy is a common problem after a young stroke and is associated with an increased short-term and long-term mortality. |
| doi_str_mv | 10.1161/STROKEAHA.115.010115 |
| format | Article |
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METHODS—We performed a prospective cohort study among 631 patients with a first-ever transient ischemic attack or ischemic stroke, aged 18 to 50 years. Survival analysis and Cox proportional hazard analysis were used to estimate cumulative mortality and hazard ratios for patients with and without epilepsy.
RESULTS—After mean follow-up of 12.5 years (SD 8.6), 76 (12.0%) developed poststroke epilepsy. Case fatality was 27.4% for patients with poststroke epilepsy and 2.1% for those without. Poststroke epilepsy was associated with 30-day mortality (hazard ratio, 4.8; 95% confidence interval, 1.7–14.0) and long-term mortality (hazard ratio, 1.8; 95% confidence interval, 1.2–2.9).
CONCLUSIONS—Epilepsy is a common problem after a young stroke and is associated with an increased short-term and long-term mortality.</description><identifier>ISSN: 0039-2499</identifier><identifier>EISSN: 1524-4628</identifier><identifier>DOI: 10.1161/STROKEAHA.115.010115</identifier><identifier>PMID: 26138118</identifier><language>eng</language><publisher>United States: American Heart Association, Inc</publisher><subject>Adult ; Age Factors ; Cohort Studies ; Epilepsy - diagnosis ; Epilepsy - etiology ; Epilepsy - mortality ; Female ; Follow-Up Studies ; Humans ; Ischemic Attack, Transient - complications ; Ischemic Attack, Transient - diagnosis ; Ischemic Attack, Transient - mortality ; Male ; Middle Aged ; Mortality - trends ; Prospective Studies ; Retrospective Studies ; Risk Factors ; Stroke - complications ; Stroke - diagnosis ; Stroke - mortality</subject><ispartof>Stroke (1970), 2015-08, Vol.46 (8), p.2309-2311</ispartof><rights>2015 American Heart Association, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3055-ac8d61b302c281aa44e5dc264ac0b9a34ee6bdc52efa7326e24db3a42f37ca463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26138118$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arntz, Renate M</creatorcontrib><creatorcontrib>Rutten-Jacobs, Loes C.A</creatorcontrib><creatorcontrib>Maaijwee, Noortje A.M</creatorcontrib><creatorcontrib>Schoonderwaldt, Hennie C</creatorcontrib><creatorcontrib>Dorresteijn, Lucille D.A</creatorcontrib><creatorcontrib>van Dijk, Ewoud J</creatorcontrib><creatorcontrib>de Leeuw, Frank-Erik</creatorcontrib><title>Poststroke Epilepsy Is Associated With a High Mortality After a Stroke at Young Age: Follow-Up of Transient Ischemic Attack and Stroke Patients and Unelucidated Risk Factor Evaluation Study</title><title>Stroke (1970)</title><addtitle>Stroke</addtitle><description>BACKGROUND AND PURPOSE—Poststroke epilepsy is a common complication after a young stroke. We investigated the association between poststroke epilepsy and mortality.
METHODS—We performed a prospective cohort study among 631 patients with a first-ever transient ischemic attack or ischemic stroke, aged 18 to 50 years. Survival analysis and Cox proportional hazard analysis were used to estimate cumulative mortality and hazard ratios for patients with and without epilepsy.
RESULTS—After mean follow-up of 12.5 years (SD 8.6), 76 (12.0%) developed poststroke epilepsy. Case fatality was 27.4% for patients with poststroke epilepsy and 2.1% for those without. Poststroke epilepsy was associated with 30-day mortality (hazard ratio, 4.8; 95% confidence interval, 1.7–14.0) and long-term mortality (hazard ratio, 1.8; 95% confidence interval, 1.2–2.9).
CONCLUSIONS—Epilepsy is a common problem after a young stroke and is associated with an increased short-term and long-term mortality.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Cohort Studies</subject><subject>Epilepsy - diagnosis</subject><subject>Epilepsy - etiology</subject><subject>Epilepsy - mortality</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Ischemic Attack, Transient - complications</subject><subject>Ischemic Attack, Transient - diagnosis</subject><subject>Ischemic Attack, Transient - mortality</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mortality - trends</subject><subject>Prospective Studies</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Stroke - complications</subject><subject>Stroke - diagnosis</subject><subject>Stroke - mortality</subject><issn>0039-2499</issn><issn>1524-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFu2zAQRIWiQeOm_YOi4LEXpSRFyVJvQmDXQVMkSGwUPQkramWxpkWFpGr44_pvZaIkx5wWs3gzC-xE0SdGzxnL2Ne79e31j0W5KoNMzymjYbyJZizlIhYZz99GM0qTIuaiKE6j9879oZTyJE_fRac8Y0nOWD6L_t0Y5523ZodkMSiNgzuSS0dK54xU4LEhv5TvCJCV2nbkp7EetPJHUrYebVjfTV7w5LcZ-y0pt_iNLI3W5hBvBmJasrbQO4W9D7myw72SpPQe5I5A3zz7b8A_IO5xt-lRj1I1j-dvlduRJUhvLFn8BT0G0vTBNzbHD9FJC9rhx6d5Fm2Wi_XFKr66_n55UV7FMqFpGoPMm4zVCeWS5wxACEwbyTMBktYFJAIxqxuZcmxhnvAMuWjqBARvk7kEkSVn0Zcpd7DmfkTnq71yErWGHs3oKjanoYCUFXlAxYRKa5yz2FaDVXuwx4rR6qG46qW4INNqKi7YPj9dGOs9Ni-m56YCkE_AwejwebfT4wFt1SFo372e_R-9qKmp</recordid><startdate>201508</startdate><enddate>201508</enddate><creator>Arntz, Renate M</creator><creator>Rutten-Jacobs, Loes C.A</creator><creator>Maaijwee, Noortje A.M</creator><creator>Schoonderwaldt, Hennie C</creator><creator>Dorresteijn, Lucille D.A</creator><creator>van Dijk, Ewoud J</creator><creator>de Leeuw, Frank-Erik</creator><general>American Heart Association, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201508</creationdate><title>Poststroke Epilepsy Is Associated With a High Mortality After a Stroke at Young Age: Follow-Up of Transient Ischemic Attack and Stroke Patients and Unelucidated Risk Factor Evaluation Study</title><author>Arntz, Renate M ; Rutten-Jacobs, Loes C.A ; Maaijwee, Noortje A.M ; Schoonderwaldt, Hennie C ; Dorresteijn, Lucille D.A ; van Dijk, Ewoud J ; de Leeuw, Frank-Erik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3055-ac8d61b302c281aa44e5dc264ac0b9a34ee6bdc52efa7326e24db3a42f37ca463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Cohort Studies</topic><topic>Epilepsy - diagnosis</topic><topic>Epilepsy - etiology</topic><topic>Epilepsy - mortality</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Ischemic Attack, Transient - complications</topic><topic>Ischemic Attack, Transient - diagnosis</topic><topic>Ischemic Attack, Transient - mortality</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mortality - trends</topic><topic>Prospective Studies</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Stroke - complications</topic><topic>Stroke - diagnosis</topic><topic>Stroke - mortality</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arntz, Renate M</creatorcontrib><creatorcontrib>Rutten-Jacobs, Loes C.A</creatorcontrib><creatorcontrib>Maaijwee, Noortje A.M</creatorcontrib><creatorcontrib>Schoonderwaldt, Hennie C</creatorcontrib><creatorcontrib>Dorresteijn, Lucille D.A</creatorcontrib><creatorcontrib>van Dijk, Ewoud J</creatorcontrib><creatorcontrib>de Leeuw, Frank-Erik</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Stroke (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arntz, Renate M</au><au>Rutten-Jacobs, Loes C.A</au><au>Maaijwee, Noortje A.M</au><au>Schoonderwaldt, Hennie C</au><au>Dorresteijn, Lucille D.A</au><au>van Dijk, Ewoud J</au><au>de Leeuw, Frank-Erik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Poststroke Epilepsy Is Associated With a High Mortality After a Stroke at Young Age: Follow-Up of Transient Ischemic Attack and Stroke Patients and Unelucidated Risk Factor Evaluation Study</atitle><jtitle>Stroke (1970)</jtitle><addtitle>Stroke</addtitle><date>2015-08</date><risdate>2015</risdate><volume>46</volume><issue>8</issue><spage>2309</spage><epage>2311</epage><pages>2309-2311</pages><issn>0039-2499</issn><eissn>1524-4628</eissn><abstract>BACKGROUND AND PURPOSE—Poststroke epilepsy is a common complication after a young stroke. We investigated the association between poststroke epilepsy and mortality.
METHODS—We performed a prospective cohort study among 631 patients with a first-ever transient ischemic attack or ischemic stroke, aged 18 to 50 years. Survival analysis and Cox proportional hazard analysis were used to estimate cumulative mortality and hazard ratios for patients with and without epilepsy.
RESULTS—After mean follow-up of 12.5 years (SD 8.6), 76 (12.0%) developed poststroke epilepsy. Case fatality was 27.4% for patients with poststroke epilepsy and 2.1% for those without. Poststroke epilepsy was associated with 30-day mortality (hazard ratio, 4.8; 95% confidence interval, 1.7–14.0) and long-term mortality (hazard ratio, 1.8; 95% confidence interval, 1.2–2.9).
CONCLUSIONS—Epilepsy is a common problem after a young stroke and is associated with an increased short-term and long-term mortality.</abstract><cop>United States</cop><pub>American Heart Association, Inc</pub><pmid>26138118</pmid><doi>10.1161/STROKEAHA.115.010115</doi><tpages>3</tpages></addata></record> |
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| source | Journals@Ovid Complete - AutoHoldings; MEDLINE; American Heart Association Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Age Factors Cohort Studies Epilepsy - diagnosis Epilepsy - etiology Epilepsy - mortality Female Follow-Up Studies Humans Ischemic Attack, Transient - complications Ischemic Attack, Transient - diagnosis Ischemic Attack, Transient - mortality Male Middle Aged Mortality - trends Prospective Studies Retrospective Studies Risk Factors Stroke - complications Stroke - diagnosis Stroke - mortality |
| title | Poststroke Epilepsy Is Associated With a High Mortality After a Stroke at Young Age: Follow-Up of Transient Ischemic Attack and Stroke Patients and Unelucidated Risk Factor Evaluation Study |
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