Novel dual-reverse thermosensitive solid lipid nanoparticle-loaded hydrogel for rectal administration of flurbiprofen with improved bioavailability and reduced initial burst effect

[Display omitted] The purpose of this study was to develop novel solid lipid nanoparticle (SLN)-loaded dual-reverse thermosensitive hydrogel (DRTH) for rectal administration of flurbiprofen with improved bioavailability and reduced initial burst effect. The flurbiprofen-loaded SLNs were prepared by...

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Veröffentlicht in:	European journal of pharmaceutics and biopharmaceutics 2015-08, Vol.94, p.64-72
Hauptverfasser:	Din, Fakhar ud, Mustapha, Omer, Kim, Dong Wuk, Rashid, Rehmana, Park, Jong Hyuck, Choi, Ju Yeon, Ku, Sae Kwang, Yong, Chul Soon, Kim, Jong Oh, Choi, Han-Gon
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesiveness Administration, Rectal Animals Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - blood Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics Area Under Curve Bioavailability Biological Availability Burst effect Chemistry, Pharmaceutical Drug Carriers Dual-reverse thermosensitive hydrogel Ethanolamines - chemistry Flurbiprofen Flurbiprofen - administration & dosage Flurbiprofen - blood Flurbiprofen - chemistry Flurbiprofen - pharmacokinetics Hot Temperature Hydrogels Male Nanomedicine Nanoparticles Particle Size Poloxamer - chemistry Rats, Sprague-Dawley Rheology Solid lipid nanoparticle Solubility Surface-Active Agents - chemistry Technology, Pharmaceutical - methods Triglycerides - chemistry Viscosity
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