Suppression of psychoactive effects of cocaine by active immunization
COCAINE is a powerfully addictive substance and new strategies are needed to treat its abuse. Generating an active immunization 1,2 to cocaine offers a means of blocking the actions of the drug by preventing it from entering the central nervous system, and should have fewer side effects than treatme...
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| Veröffentlicht in: | Nature (London) 1995-12, Vol.378 (6558), p.727-730 |
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| creator | Carrera, M. Rocío A Ashley, Jon A Parsons, Loren H Wirsching, Peter Koob, George F Janda, Kim D |
| description | COCAINE is a powerfully addictive substance and new strategies are needed to treat its abuse. Generating an active immunization
1,2
to cocaine offers a means of blocking the actions of the drug by preventing it from entering the central nervous system, and should have fewer side effects than treatments based on manipulation of central neurotransmitter function. The design and preparation of a cocaine immunogen requires special regard for the stability of cocaine both free and as a haptenic determinant. Immunochemistry and a well defined behavioural model were brought together to address the problem of inactivation of the psychostimulant actions of cocaine. We report here that active immunization with a new, stable cocaine conjugate suppressed locomotor activity and stereotyped behaviour in rats induced by cocaine but not by amphetamine. Moreover, following acute injection of cocaine, levels of cocaine in the striatum and cerebellum of the immunized animals were lower than those of control animals. These results suggest that immunopharmacotherapy may be a promising means by which to explore new treatments for cocaine abuse. |
| doi_str_mv | 10.1038/378727a0 |
| format | Article |
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1,2
to cocaine offers a means of blocking the actions of the drug by preventing it from entering the central nervous system, and should have fewer side effects than treatments based on manipulation of central neurotransmitter function. The design and preparation of a cocaine immunogen requires special regard for the stability of cocaine both free and as a haptenic determinant. Immunochemistry and a well defined behavioural model were brought together to address the problem of inactivation of the psychostimulant actions of cocaine. We report here that active immunization with a new, stable cocaine conjugate suppressed locomotor activity and stereotyped behaviour in rats induced by cocaine but not by amphetamine. Moreover, following acute injection of cocaine, levels of cocaine in the striatum and cerebellum of the immunized animals were lower than those of control animals. These results suggest that immunopharmacotherapy may be a promising means by which to explore new treatments for cocaine abuse.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/378727a0</identifier><identifier>PMID: 7501020</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Amphetamines ; Animals ; Antibodies - immunology ; Antigens ; Biological and medical sciences ; Brain - metabolism ; Central nervous system ; Cocaine ; Cocaine - antagonists & inhibitors ; Cocaine - immunology ; Cocaine - pharmacokinetics ; Dopamine ; Drug abuse ; Drug addictions ; Drug dosages ; Haptens - immunology ; Hemocyanins - immunology ; Humanities and Social Sciences ; Immunization ; Immunoconjugates - immunology ; Inactivation ; letter ; Locomotor activity ; Male ; Medical sciences ; Metabolites ; Monoclonal antibodies ; multidisciplinary ; Psychomotor Performance ; Rats ; Rats, Wistar ; Science ; Science (multidisciplinary) ; Side effects ; Substance-Related Disorders - immunology ; Substance-Related Disorders - metabolism ; Substance-Related Disorders - prevention & control ; Toxicology ; Vaccination</subject><ispartof>Nature (London), 1995-12, Vol.378 (6558), p.727-730</ispartof><rights>Springer Nature Limited 1995</rights><rights>1996 INIST-CNRS</rights><rights>Copyright Macmillan Journals Ltd. Dec 14, 1995</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c488t-2f60f75998da312f1bda6a76d232c0dced2200f6e287c3fc434b575840f5a48c3</citedby><cites>FETCH-LOGICAL-c488t-2f60f75998da312f1bda6a76d232c0dced2200f6e287c3fc434b575840f5a48c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2727,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2922187$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7501020$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carrera, M. Rocío A</creatorcontrib><creatorcontrib>Ashley, Jon A</creatorcontrib><creatorcontrib>Parsons, Loren H</creatorcontrib><creatorcontrib>Wirsching, Peter</creatorcontrib><creatorcontrib>Koob, George F</creatorcontrib><creatorcontrib>Janda, Kim D</creatorcontrib><title>Suppression of psychoactive effects of cocaine by active immunization</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>COCAINE is a powerfully addictive substance and new strategies are needed to treat its abuse. Generating an active immunization
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to cocaine offers a means of blocking the actions of the drug by preventing it from entering the central nervous system, and should have fewer side effects than treatments based on manipulation of central neurotransmitter function. The design and preparation of a cocaine immunogen requires special regard for the stability of cocaine both free and as a haptenic determinant. Immunochemistry and a well defined behavioural model were brought together to address the problem of inactivation of the psychostimulant actions of cocaine. We report here that active immunization with a new, stable cocaine conjugate suppressed locomotor activity and stereotyped behaviour in rats induced by cocaine but not by amphetamine. Moreover, following acute injection of cocaine, levels of cocaine in the striatum and cerebellum of the immunized animals were lower than those of control animals. These results suggest that immunopharmacotherapy may be a promising means by which to explore new treatments for cocaine abuse.</description><subject>Amphetamines</subject><subject>Animals</subject><subject>Antibodies - immunology</subject><subject>Antigens</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>Central nervous system</subject><subject>Cocaine</subject><subject>Cocaine - antagonists & inhibitors</subject><subject>Cocaine - immunology</subject><subject>Cocaine - pharmacokinetics</subject><subject>Dopamine</subject><subject>Drug abuse</subject><subject>Drug addictions</subject><subject>Drug dosages</subject><subject>Haptens - immunology</subject><subject>Hemocyanins - immunology</subject><subject>Humanities and Social Sciences</subject><subject>Immunization</subject><subject>Immunoconjugates - immunology</subject><subject>Inactivation</subject><subject>letter</subject><subject>Locomotor activity</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolites</subject><subject>Monoclonal antibodies</subject><subject>multidisciplinary</subject><subject>Psychomotor Performance</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Side effects</subject><subject>Substance-Related Disorders - immunology</subject><subject>Substance-Related Disorders - metabolism</subject><subject>Substance-Related Disorders - prevention & control</subject><subject>Toxicology</subject><subject>Vaccination</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkFtLxDAQhYMo67oK_gGliIg-VCeXJumjLOsFFnxQn0uaJtplezFphfXX26W1gvg0MOebM4eD0DGGawxU3lAhBREKdtAUM8FDxqXYRVMAIkOQlO-jA-9XABBhwSZoIiLAQGCKFs9tXTvjfV6VQWWD2m_0e6V0k3-awFhrdOO3e11plZcmSDfBIOZF0Zb5l2q6y0O0Z9Xam6NhztDr3eJl_hAun-4f57fLUDMpm5BYDlZEcSwzRTGxOM0UV4JnhBINmTYZIQCWGyKFplYzytJIRJKBjRSTms7QRe9bu-qjNb5Jitxrs16r0lStTzCPO3MhOvDsD7iqWld22RICjEUxo7yDLntIu8p7Z2xSu7xQbpNgSLa1Jj-1dujJ4NemhclGcOix088HXXmt1tapUud-xEhMCJbbWFc95julfDPuN9Y_L097tlRN68zoNQLfA36VLg</recordid><startdate>19951214</startdate><enddate>19951214</enddate><creator>Carrera, M. 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Rocío A</au><au>Ashley, Jon A</au><au>Parsons, Loren H</au><au>Wirsching, Peter</au><au>Koob, George F</au><au>Janda, Kim D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Suppression of psychoactive effects of cocaine by active immunization</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1995-12-14</date><risdate>1995</risdate><volume>378</volume><issue>6558</issue><spage>727</spage><epage>730</epage><pages>727-730</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><coden>NATUAS</coden><abstract>COCAINE is a powerfully addictive substance and new strategies are needed to treat its abuse. Generating an active immunization
1,2
to cocaine offers a means of blocking the actions of the drug by preventing it from entering the central nervous system, and should have fewer side effects than treatments based on manipulation of central neurotransmitter function. The design and preparation of a cocaine immunogen requires special regard for the stability of cocaine both free and as a haptenic determinant. Immunochemistry and a well defined behavioural model were brought together to address the problem of inactivation of the psychostimulant actions of cocaine. We report here that active immunization with a new, stable cocaine conjugate suppressed locomotor activity and stereotyped behaviour in rats induced by cocaine but not by amphetamine. Moreover, following acute injection of cocaine, levels of cocaine in the striatum and cerebellum of the immunized animals were lower than those of control animals. These results suggest that immunopharmacotherapy may be a promising means by which to explore new treatments for cocaine abuse.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>7501020</pmid><doi>10.1038/378727a0</doi><tpages>4</tpages></addata></record> |
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| issn | 0028-0836 1476-4687 |
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| subjects | Amphetamines Animals Antibodies - immunology Antigens Biological and medical sciences Brain - metabolism Central nervous system Cocaine Cocaine - antagonists & inhibitors Cocaine - immunology Cocaine - pharmacokinetics Dopamine Drug abuse Drug addictions Drug dosages Haptens - immunology Hemocyanins - immunology Humanities and Social Sciences Immunization Immunoconjugates - immunology Inactivation letter Locomotor activity Male Medical sciences Metabolites Monoclonal antibodies multidisciplinary Psychomotor Performance Rats Rats, Wistar Science Science (multidisciplinary) Side effects Substance-Related Disorders - immunology Substance-Related Disorders - metabolism Substance-Related Disorders - prevention & control Toxicology Vaccination |
| title | Suppression of psychoactive effects of cocaine by active immunization |
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