Induction of 15-lipoxygenase by interleukin-13 in human blood monocytes
15-Lipoxygenase (15-LO) catalyzes hydroperoxidation of fatty acids, a reaction of potential relevance to inflammation, membrane remodeling, and atherosclerosis. In human leukocytes, 15-lipoxygenation of arachidonic acid produces 15-(S)-hydroxyeicosatetraenoic acid and lipoxin A4, which suppress whit...
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| Veröffentlicht in: | The Journal of biological chemistry 1994-11, Vol.269 (44), p.27631-27634 |
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| container_title | The Journal of biological chemistry |
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| creator | Nassar, G M Morrow, J D Roberts, L J Lakkis, F G Badr, K F |
| description | 15-Lipoxygenase (15-LO) catalyzes hydroperoxidation of fatty acids, a reaction of potential relevance to inflammation, membrane remodeling, and atherosclerosis. In human leukocytes, 15-lipoxygenation of arachidonic acid produces 15-(S)-hydroxyeicosatetraenoic acid and lipoxin A4, which suppress white cell chemotaxis, adherence, and activation, and antagonize proinflammatory leukotrienes. Interleukin (IL)-13, produced by T-helper subset 2 (TH-2) lymphocytes, specifically and potently induced 15-LO gene expression and enzyme activity in human monocytes. Among other TH-2 lymphokines, this induction of 15-LO is shared by IL-4 but not by IL-10. Interferon-gamma, a product of TH-1 lymphocytes, blocked IL-13-mediated induction of 15-LO. The induction of the anti-inflammatory 15-LO pathway by IL-13 reveals a new facet of IL-13 biology that supports its role as a cytokine with potential to down-regulate inflammatory pathways. The contrasting effects of interferon-gamma and IL-13 on 15-LO induction demonstrate mechanisms by which T-lymphocyte subsets may modulate macrophage/monocyte function in inflammation or atherosclerosis. |
| doi_str_mv | 10.1016/S0021-9258(18)47031-7 |
| format | Article |
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In human leukocytes, 15-lipoxygenation of arachidonic acid produces 15-(S)-hydroxyeicosatetraenoic acid and lipoxin A4, which suppress white cell chemotaxis, adherence, and activation, and antagonize proinflammatory leukotrienes. Interleukin (IL)-13, produced by T-helper subset 2 (TH-2) lymphocytes, specifically and potently induced 15-LO gene expression and enzyme activity in human monocytes. Among other TH-2 lymphokines, this induction of 15-LO is shared by IL-4 but not by IL-10. Interferon-gamma, a product of TH-1 lymphocytes, blocked IL-13-mediated induction of 15-LO. The induction of the anti-inflammatory 15-LO pathway by IL-13 reveals a new facet of IL-13 biology that supports its role as a cytokine with potential to down-regulate inflammatory pathways. The contrasting effects of interferon-gamma and IL-13 on 15-LO induction demonstrate mechanisms by which T-lymphocyte subsets may modulate macrophage/monocyte function in inflammation or atherosclerosis.</description><identifier>ISSN: 0021-9258</identifier><identifier>EISSN: 1083-351X</identifier><identifier>DOI: 10.1016/S0021-9258(18)47031-7</identifier><identifier>PMID: 7961680</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Arachidonate 15-Lipoxygenase - biosynthesis ; Base Sequence ; DNA Primers - chemistry ; Gene Expression - drug effects ; Humans ; Hydroxyeicosatetraenoic Acids - metabolism ; In Vitro Techniques ; Interleukin-10 - pharmacology ; Interleukin-13 - pharmacology ; Interleukin-4 - pharmacology ; Molecular Sequence Data ; Monocytes - enzymology ; RNA, Messenger - genetics</subject><ispartof>The Journal of biological chemistry, 1994-11, Vol.269 (44), p.27631-27634</ispartof><rights>1994 © 1994 ASBMB. 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In human leukocytes, 15-lipoxygenation of arachidonic acid produces 15-(S)-hydroxyeicosatetraenoic acid and lipoxin A4, which suppress white cell chemotaxis, adherence, and activation, and antagonize proinflammatory leukotrienes. Interleukin (IL)-13, produced by T-helper subset 2 (TH-2) lymphocytes, specifically and potently induced 15-LO gene expression and enzyme activity in human monocytes. Among other TH-2 lymphokines, this induction of 15-LO is shared by IL-4 but not by IL-10. Interferon-gamma, a product of TH-1 lymphocytes, blocked IL-13-mediated induction of 15-LO. The induction of the anti-inflammatory 15-LO pathway by IL-13 reveals a new facet of IL-13 biology that supports its role as a cytokine with potential to down-regulate inflammatory pathways. The contrasting effects of interferon-gamma and IL-13 on 15-LO induction demonstrate mechanisms by which T-lymphocyte subsets may modulate macrophage/monocyte function in inflammation or atherosclerosis.</description><subject>Arachidonate 15-Lipoxygenase - biosynthesis</subject><subject>Base Sequence</subject><subject>DNA Primers - chemistry</subject><subject>Gene Expression - drug effects</subject><subject>Humans</subject><subject>Hydroxyeicosatetraenoic Acids - metabolism</subject><subject>In Vitro Techniques</subject><subject>Interleukin-10 - pharmacology</subject><subject>Interleukin-13 - pharmacology</subject><subject>Interleukin-4 - pharmacology</subject><subject>Molecular Sequence Data</subject><subject>Monocytes - enzymology</subject><subject>RNA, Messenger - genetics</subject><issn>0021-9258</issn><issn>1083-351X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1P3DAQhi1URJePn4CUQ1WVQ6gnTvxxqtAKFiQkDoDEzUqc8a7bxN7GSWH_fQ272itz8VjzvGPrIeQc6CVQ4D8fKS0gV0Ulf4C8KAVlkIsDMgMqWc4qePlCZnvkKzmO8TdNVSo4IkdCceCSzsjizreTGV3wWbAZVHnn1uFts0RfR8yaTeb8iEOH0x_nc2Dpmq2mvvZZ04XQZn3wwWxGjKfk0NZdxLPdeUKeb66f5rf5_cPibn51n5uKsTFHYMwCrbEQkssCbVkWQBVtqGzAWtvWCFABZ3XBLJOJFtKkXtCSKSMYOyHft3vXQ_g7YRx176LBrqs9hilq4EpJxcsEVlvQDCHGAa1eD66vh40Gqt8F6g-B-t2OBqk_BGqRcue7B6amx3af2hlL82_b-cotV69uQN24YFbY64IrXZa6EJxBwn5tMUwy_jkcdDQOvcE2Rcyo2-A--ch_Bz2J8Q</recordid><startdate>19941104</startdate><enddate>19941104</enddate><creator>Nassar, G M</creator><creator>Morrow, J D</creator><creator>Roberts, L J</creator><creator>Lakkis, F G</creator><creator>Badr, K F</creator><general>Elsevier Inc</general><general>American Society for Biochemistry and Molecular Biology</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>19941104</creationdate><title>Induction of 15-lipoxygenase by interleukin-13 in human blood monocytes</title><author>Nassar, G M ; Morrow, J D ; Roberts, L J ; Lakkis, F G ; Badr, K F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c533t-e133f10ae278682ef4421090b08b1fffdae115163a23f3813378ca2370439c733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Arachidonate 15-Lipoxygenase - biosynthesis</topic><topic>Base Sequence</topic><topic>DNA Primers - chemistry</topic><topic>Gene Expression - drug effects</topic><topic>Humans</topic><topic>Hydroxyeicosatetraenoic Acids - metabolism</topic><topic>In Vitro Techniques</topic><topic>Interleukin-10 - pharmacology</topic><topic>Interleukin-13 - pharmacology</topic><topic>Interleukin-4 - pharmacology</topic><topic>Molecular Sequence Data</topic><topic>Monocytes - enzymology</topic><topic>RNA, Messenger - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nassar, G M</creatorcontrib><creatorcontrib>Morrow, J D</creatorcontrib><creatorcontrib>Roberts, L J</creatorcontrib><creatorcontrib>Lakkis, F G</creatorcontrib><creatorcontrib>Badr, K F</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>The Journal of biological chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nassar, G M</au><au>Morrow, J D</au><au>Roberts, L J</au><au>Lakkis, F G</au><au>Badr, K F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Induction of 15-lipoxygenase by interleukin-13 in human blood monocytes</atitle><jtitle>The Journal of biological chemistry</jtitle><addtitle>J Biol Chem</addtitle><date>1994-11-04</date><risdate>1994</risdate><volume>269</volume><issue>44</issue><spage>27631</spage><epage>27634</epage><pages>27631-27634</pages><issn>0021-9258</issn><eissn>1083-351X</eissn><abstract>15-Lipoxygenase (15-LO) catalyzes hydroperoxidation of fatty acids, a reaction of potential relevance to inflammation, membrane remodeling, and atherosclerosis. In human leukocytes, 15-lipoxygenation of arachidonic acid produces 15-(S)-hydroxyeicosatetraenoic acid and lipoxin A4, which suppress white cell chemotaxis, adherence, and activation, and antagonize proinflammatory leukotrienes. Interleukin (IL)-13, produced by T-helper subset 2 (TH-2) lymphocytes, specifically and potently induced 15-LO gene expression and enzyme activity in human monocytes. Among other TH-2 lymphokines, this induction of 15-LO is shared by IL-4 but not by IL-10. Interferon-gamma, a product of TH-1 lymphocytes, blocked IL-13-mediated induction of 15-LO. The induction of the anti-inflammatory 15-LO pathway by IL-13 reveals a new facet of IL-13 biology that supports its role as a cytokine with potential to down-regulate inflammatory pathways. The contrasting effects of interferon-gamma and IL-13 on 15-LO induction demonstrate mechanisms by which T-lymphocyte subsets may modulate macrophage/monocyte function in inflammation or atherosclerosis.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>7961680</pmid><doi>10.1016/S0021-9258(18)47031-7</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of biological chemistry, 1994-11, Vol.269 (44), p.27631-27634 |
| issn | 0021-9258 1083-351X |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Arachidonate 15-Lipoxygenase - biosynthesis Base Sequence DNA Primers - chemistry Gene Expression - drug effects Humans Hydroxyeicosatetraenoic Acids - metabolism In Vitro Techniques Interleukin-10 - pharmacology Interleukin-13 - pharmacology Interleukin-4 - pharmacology Molecular Sequence Data Monocytes - enzymology RNA, Messenger - genetics |
| title | Induction of 15-lipoxygenase by interleukin-13 in human blood monocytes |
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