Progressive Growth in Immunodeficient Mice and Host Cell Recruitment by Mouse Endothelial Cells Transformed by Polyoma Middle-Sized T Antigen: Implications for the Pathogenesis of Opportunistic Vascular Tumors

A retroviral construct encoding polyoma middle-sized T antigen was used to generate transformed endothelial cell lines from heart (H5V), brain (B9V), and whole-embryo (E10V) of C57BL/6 mice. When injected into syngeneic recipients, H5V and the less studied B9V and E10V cells caused vascular tumors w...

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