Hepatotoxicity and transaminase measurement during isoniazid chemoprophylaxis in children
Chemoprophylaxis with isoniazid (INH) prevents progression from tuberculosis infection to disease in >99% of children. INH is not completely free of side effects or risks, but these are uncommon. Although allergy, rash, gastrointestinal upset, peripheral neuropathy, seizures, encephalopathy and o...
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| Veröffentlicht in: | The Pediatric infectious disease journal 1995-02, Vol.14 (2), p.144-148 |
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| container_end_page | 148 |
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| container_title | The Pediatric infectious disease journal |
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| creator | A, VINCENT PALUSCI OHARE, DONNA LAWRENCE, ROBERT M |
| description | Chemoprophylaxis with isoniazid (INH) prevents progression from tuberculosis infection to disease in >99% of children. INH is not completely free of side effects or risks, but these are uncommon. Although allergy, rash, gastrointestinal upset, peripheral neuropathy, seizures, encephalopathy and other reactions have been reported, the major side effect of INH is hepatitis. During 1993 a child was treated at our institution for fulminant hepatitis associated with INH. This prompted a review of the charts of all children treated at our children's chest clinic during the prior 2 years to assess the presentation of hepatotoxicity and the role of transaminase measurement during INH chemoprophylaxis in children. |
| doi_str_mv | 10.1097/00006454-199502000-00012 |
| format | Article |
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INH is not completely free of side effects or risks, but these are uncommon. Although allergy, rash, gastrointestinal upset, peripheral neuropathy, seizures, encephalopathy and other reactions have been reported, the major side effect of INH is hepatitis. During 1993 a child was treated at our institution for fulminant hepatitis associated with INH. This prompted a review of the charts of all children treated at our children's chest clinic during the prior 2 years to assess the presentation of hepatotoxicity and the role of transaminase measurement during INH chemoprophylaxis in children.</description><identifier>ISSN: 0891-3668</identifier><identifier>EISSN: 1532-0987</identifier><identifier>DOI: 10.1097/00006454-199502000-00012</identifier><identifier>PMID: 7746698</identifier><identifier>CODEN: PIDJEV</identifier><language>eng</language><publisher>Baltimore, MD: Williams & Wilkins</publisher><subject>Adolescent ; Biological and medical sciences ; Chemical and Drug Induced Liver Injury - diagnosis ; Chemical and Drug Induced Liver Injury - enzymology ; Chemical and Drug Induced Liver Injury - etiology ; Child ; Child, Preschool ; Drug toxicity and drugs side effects treatment ; Female ; Humans ; Incidence ; Infant ; Isoniazid - adverse effects ; Isoniazid - therapeutic use ; Liver Function Tests ; Male ; Medical sciences ; Pharmacology. Drug treatments ; Prognosis ; Retrospective Studies ; Toxicity: digestive system ; Transaminases - blood ; Tuberculosis - drug therapy</subject><ispartof>The Pediatric infectious disease journal, 1995-02, Vol.14 (2), p.144-148</ispartof><rights>Williams & Wilkins 1995. 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INH is not completely free of side effects or risks, but these are uncommon. Although allergy, rash, gastrointestinal upset, peripheral neuropathy, seizures, encephalopathy and other reactions have been reported, the major side effect of INH is hepatitis. During 1993 a child was treated at our institution for fulminant hepatitis associated with INH. This prompted a review of the charts of all children treated at our children's chest clinic during the prior 2 years to assess the presentation of hepatotoxicity and the role of transaminase measurement during INH chemoprophylaxis in children.</description><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>Chemical and Drug Induced Liver Injury - diagnosis</subject><subject>Chemical and Drug Induced Liver Injury - enzymology</subject><subject>Chemical and Drug Induced Liver Injury - etiology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infant</subject><subject>Isoniazid - adverse effects</subject><subject>Isoniazid - therapeutic use</subject><subject>Liver Function Tests</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Toxicity: digestive system</subject><subject>Transaminases - blood</subject><subject>Tuberculosis - drug therapy</subject><issn>0891-3668</issn><issn>1532-0987</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUtP3DAQgK2qFSy0P6FSDqi3gB-JH0eEWkBC4gKHnqypPem6dZzFTgTbX1_TXfZWS5Zlzze25xtCGkbPGTXqgtYhu75rmTE95XXX1sn4O7JiveAtNVq9JyuqDWuFlPqYnJTyqyKiY_SIHCnVSWn0iny_wQ3M0zy9BBfmbQPJN3OGVGAMCQo2I0JZMo6Y5sYvOaSfTShTCvAn-MatcZw2edqstxFeQmlCqmch-ozpI_kwQCz4ab-eksdvXx-ubtq7--vbq8u71nXC8BaNAW44R94DesVErxgqjwOjlBslmUDQ_cA6PTjvtPIStJaeqV7U4sQgTsmX3b31H08LltmOoTiMERJOS7FMGqOY1BXUO9DlqZSMg93kMELeWkbtq1X7ZtUerNp_Vmvq5_0by48R_SFxr7HGz_ZxKA7iUAW6UA5Ylc41ZRXrdtjzFGfM5XdcnjHbNUKc1_Z_PRV_AaaskAs</recordid><startdate>199502</startdate><enddate>199502</enddate><creator>A, VINCENT</creator><creator>PALUSCI</creator><creator>OHARE, DONNA</creator><creator>LAWRENCE, ROBERT M</creator><general>Williams & Wilkins</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>199502</creationdate><title>Hepatotoxicity and transaminase measurement during isoniazid chemoprophylaxis in children</title><author>A, VINCENT ; PALUSCI ; OHARE, DONNA ; LAWRENCE, ROBERT M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4392-e99a2922e25aed713571e7def100297613ea85f148fcdc87d6a886d17538913f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adolescent</topic><topic>Biological and medical sciences</topic><topic>Chemical and Drug Induced Liver Injury - diagnosis</topic><topic>Chemical and Drug Induced Liver Injury - enzymology</topic><topic>Chemical and Drug Induced Liver Injury - etiology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infant</topic><topic>Isoniazid - adverse effects</topic><topic>Isoniazid - therapeutic use</topic><topic>Liver Function Tests</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Toxicity: digestive system</topic><topic>Transaminases - blood</topic><topic>Tuberculosis - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>A, VINCENT</creatorcontrib><creatorcontrib>PALUSCI</creatorcontrib><creatorcontrib>OHARE, DONNA</creatorcontrib><creatorcontrib>LAWRENCE, ROBERT M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>The Pediatric infectious disease journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>A, VINCENT</au><au>PALUSCI</au><au>OHARE, DONNA</au><au>LAWRENCE, ROBERT M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatotoxicity and transaminase measurement during isoniazid chemoprophylaxis in children</atitle><jtitle>The Pediatric infectious disease journal</jtitle><addtitle>Pediatr Infect Dis J</addtitle><date>1995-02</date><risdate>1995</risdate><volume>14</volume><issue>2</issue><spage>144</spage><epage>148</epage><pages>144-148</pages><issn>0891-3668</issn><eissn>1532-0987</eissn><coden>PIDJEV</coden><abstract>Chemoprophylaxis with isoniazid (INH) prevents progression from tuberculosis infection to disease in >99% of children. INH is not completely free of side effects or risks, but these are uncommon. Although allergy, rash, gastrointestinal upset, peripheral neuropathy, seizures, encephalopathy and other reactions have been reported, the major side effect of INH is hepatitis. During 1993 a child was treated at our institution for fulminant hepatitis associated with INH. This prompted a review of the charts of all children treated at our children's chest clinic during the prior 2 years to assess the presentation of hepatotoxicity and the role of transaminase measurement during INH chemoprophylaxis in children.</abstract><cop>Baltimore, MD</cop><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>Williams & Wilkins</pub><pmid>7746698</pmid><doi>10.1097/00006454-199502000-00012</doi><tpages>5</tpages></addata></record> |
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| ispartof | The Pediatric infectious disease journal, 1995-02, Vol.14 (2), p.144-148 |
| issn | 0891-3668 1532-0987 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adolescent Biological and medical sciences Chemical and Drug Induced Liver Injury - diagnosis Chemical and Drug Induced Liver Injury - enzymology Chemical and Drug Induced Liver Injury - etiology Child Child, Preschool Drug toxicity and drugs side effects treatment Female Humans Incidence Infant Isoniazid - adverse effects Isoniazid - therapeutic use Liver Function Tests Male Medical sciences Pharmacology. Drug treatments Prognosis Retrospective Studies Toxicity: digestive system Transaminases - blood Tuberculosis - drug therapy |
| title | Hepatotoxicity and transaminase measurement during isoniazid chemoprophylaxis in children |
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