Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis

Glucocorticoids are among the most potent anti-inflammatory and immunosuppressive agents. They inhibit synthesis of almost all known cytokines and of several cell surface molecules required for immune function, but the mechanism underlying this activity has been unclear. Here it is shown that glucoc...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1995-10, Vol.270 (5234), p.286-290
Hauptverfasser:	Auphan, Nathalie, DiDonato, Joseph A., Rosette, Caridad, Helmberg, Arno, Karin, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Antibodies Antiinflammatories Biological and medical sciences Cell Line Cell lines Cell nucleus Cell Nucleus - metabolism Cellular immunity Cytoplasm Cytoplasm - metabolism Dexamethasone - pharmacology DNA-Binding Proteins - biosynthesis Fundamental and applied biological sciences. Psychology Genes Glucocorticoids HeLa cells Humans Hybridomas I-kappa B Proteins Immunosuppression Interleukin-2 - pharmacology Lymph Nodes - drug effects Lymph Nodes - metabolism Mice Molecular and cellular biology Molecular genetics NF-kappa B - antagonists & inhibitors NF-kappa B - metabolism NF-KappaB Inhibitor alpha Receptors, Glucocorticoid - metabolism T lymphocytes T-Lymphocytes - drug effects T-Lymphocytes - metabolism Tetradecanoylphorbol Acetate - pharmacology Transcription Factor AP-1 - metabolism Transcription Factor RelA Transcription. Transcription factor. Splicing. Rna processing Tumor Cells, Cultured
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