Neuropharmacokinetic evaluation of methotrexate-loaded chitosan nanogels

Delivery of the hydrophilic drugs to the brain is still a great challenge for the treatment of many CNS-related diseases. Nanogels loaded by methotrexate (MTX) were prepared using the ionic gelation method. After intravenous administration of surface-modified (SMNs) and unmodified nanogels (UMNs) co...

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Veröffentlicht in:	International journal of biological macromolecules 2015-08, Vol.79, p.326-335
Hauptverfasser:	Azadi, Amir, Rouini, Mohammad-Reza, Hamidi, Mehrdad
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimetabolites, Antineoplastic - blood Antimetabolites, Antineoplastic - pharmacokinetics Blood-Brain Barrier - metabolism Blood–brain barrier Brain - metabolism Capillary Permeability Chitosan - chemistry Drug Compounding Drug Delivery Systems - methods Drug Liberation Gels Half-Life Hydrogel nanoparticles Injections, Intravenous Male Methotrexate Methotrexate - blood Methotrexate - pharmacokinetics Nanostructures - chemistry Nanostructures - ultrastructure Particle Size Rats Rats, Sprague-Dawley Surface modification Surface Properties Uptake clearance
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