Sickle cell anemia induces changes in peripheral lymphocytes E-NTPDase/E-ADA activities and cytokines secretion in patients under treatment

Abstract Sickle cell anemia (SCA) is characterized by hemoglobin polymerization that results in sickle-shaped red blood cells. The vascular obstruction by sickle erythrocytes is often inflammatory, and purinergic system ecto-enzymes play an important role in modulating the inflammatory and immune re...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2015-07, Vol.73, p.102-108
Hauptverfasser:	Castilhos, Lívia G, Doleski, Pedro H, Bertoldo, Tatiana M.D, Passos, Daniela F, Bertoncheli, Claudia de M, Rezer, João F.P, Schlemmer, Josiane B, Leal, Daniela B.R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Deaminase - blood Adenosine Triphosphatases - blood Adolescent Adult Anemia, Sickle Cell - blood Anemia, Sickle Cell - enzymology Anemia, Sickle Cell - therapy Case-Control Studies Cytokines Cytokines - blood E-ADA E-NTPDase Female Humans Internal Medicine Lymphocytes - enzymology Male Medical Education Middle Aged Sickle cell anemia Treatment Outcome Young Adult
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