Rotenone affects p53 transcriptional activity and apoptosis via targeting SIRT1 and H3K9 acetylation in SH‐SY5Y cells

The protein deacetylase SIRT1 has been recognized to exert its protective effect by directly deacetylasing histone and many other transcriptional factors including p53. However, the effect of SIRT1 on p53 expression at the transcriptional level still remains to be elucidated. In this study, we found...

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Veröffentlicht in:	Journal of neurochemistry 2015-08, Vol.134 (4), p.668-676
Hauptverfasser:	Feng, Ya, Liu, Te, Dong, Su‐Yan, Guo, Yan‐Jie, Jankovic, Joseph, Xu, Huaxi, Wu, Yun‐Cheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation - drug effects Apoptosis Apoptosis - drug effects Apoptosis - physiology Cell Line, Tumor Cell Survival - drug effects Cell Survival - physiology Drug Delivery Systems - methods Gene expression Genes, p53 - drug effects Genes, p53 - physiology H3K9‐ac H3K9‐me3 Histones - metabolism Humans p53 Parkinson's disease resveratrol Rotenone - administration & dosage Rotenone - metabolism SIRT1 Sirtuin 1 - metabolism Transcription, Genetic - drug effects Transcription, Genetic - physiology
Online-Zugang:	Volltext
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