Effects of kanamycin ototoxicity and hair cell regeneration on the DC endocochlear potential in adult chickens
High doses of aminoglycoside antibiotics cause massive damage to the avian basilar papilla. The resulting functional loss could conceivably arise from the reduction in the DC endocochlear potential (EP) due to impairment of the tegmentum vasculosum (TV) or to shunting of current through the damaged...
Gespeichert in:
| Veröffentlicht in: | Hearing research 1995-09, Vol.89 (1), p.28-34 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 34 |
|---|---|
| container_issue | 1 |
| container_start_page | 28 |
| container_title | Hearing research |
| container_volume | 89 |
| creator | Chen, Lin Trautwein, Patricia G. Miller, Karen Salvi, Richard J. |
| description | High doses of aminoglycoside antibiotics cause massive damage to the avian basilar papilla. The resulting functional loss could conceivably arise from the reduction in the DC endocochlear potential (EP) due to impairment of the tegmentum vasculosum (TV) or to shunting of current through the damaged sensory epithelium. To test this hypothesis, the EP was measured in adult chickens after destroying hair cells in the basal half of the cochlea with a high dose (400 mg/kg per day for 10 days) of kanamycin (KM). KM treatment caused an increase in the steady-state EP from +18.1 to +23.3 mV and a decrease in the magnitude of the negative EP from −42.0 to −19.2 mV. The EP showed almost no change between 1 and 2 days and 1 week post-KM treatment. After 4 weeks of recovery, most hair cells had regenerated; however, the steady-state EP was still elevated by 13% and the negative EP was depressed by 37%. These results suggest that functional loss as shown by the large reduction in cochlear microphonic (CM) and the elevated thresholds of compound action potential (CAP) following KM treatment is not due to a reduction in the EP but may arise from functional deficits in the hair cells and/or the auditory nerve. |
| doi_str_mv | 10.1016/0378-5955(95)00119-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_16994351</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0378595595001195</els_id><sourcerecordid>16994351</sourcerecordid><originalsourceid>FETCH-LOGICAL-c417t-6fb36dcc48937795652e43afee2f476c4e7d511ca8a6f242c30869142d6f22aa3</originalsourceid><addsrcrecordid>eNp9kU2PFCEQhonRrLOr_0ATDsash9amge7msokZ149kEy96JrXVhYPbAyMwxvn30s5kjoYDH_XUG3hg7IVo34pW9O9aOYyNNlpfG_2mbYUwjX7EVmJcjkcjHrPVGXnKLnP-WSEtVXfBLsa-rmW7YuHWOcKSeXT8AQJsD-gDj6WOPx59OXAIE9-ATxxpnnmiHxQoQfGxYoGXDfEPa05hihhxMxMkvouFQvEw8xoF034uHDceHyjkZ-yJgznT89N8xb5_vP22_tzcff30Zf3-rkElhtL07l72E6IajRwGo3vdkZLgiDqnhh4VDZMWAmGE3nWqQ9mOvRGqm-q2A5BX7PUxd5firz3lYrc-Lw-AQHGfreiNUVKLCqojiCnmnMjZXfJbSAcrWrtototDuzi0Rtt_mq2ubS9P-fv7LU3nppPXWn91qkNGmF2CgD6fsc7IsRtVxW6OGFUXvz0lm9FTQJp8qr9ip-j_f4-_phSZvQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16994351</pqid></control><display><type>article</type><title>Effects of kanamycin ototoxicity and hair cell regeneration on the DC endocochlear potential in adult chickens</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Chen, Lin ; Trautwein, Patricia G. ; Miller, Karen ; Salvi, Richard J.</creator><creatorcontrib>Chen, Lin ; Trautwein, Patricia G. ; Miller, Karen ; Salvi, Richard J.</creatorcontrib><description>High doses of aminoglycoside antibiotics cause massive damage to the avian basilar papilla. The resulting functional loss could conceivably arise from the reduction in the DC endocochlear potential (EP) due to impairment of the tegmentum vasculosum (TV) or to shunting of current through the damaged sensory epithelium. To test this hypothesis, the EP was measured in adult chickens after destroying hair cells in the basal half of the cochlea with a high dose (400 mg/kg per day for 10 days) of kanamycin (KM). KM treatment caused an increase in the steady-state EP from +18.1 to +23.3 mV and a decrease in the magnitude of the negative EP from −42.0 to −19.2 mV. The EP showed almost no change between 1 and 2 days and 1 week post-KM treatment. After 4 weeks of recovery, most hair cells had regenerated; however, the steady-state EP was still elevated by 13% and the negative EP was depressed by 37%. These results suggest that functional loss as shown by the large reduction in cochlear microphonic (CM) and the elevated thresholds of compound action potential (CAP) following KM treatment is not due to a reduction in the EP but may arise from functional deficits in the hair cells and/or the auditory nerve.</description><identifier>ISSN: 0378-5955</identifier><identifier>EISSN: 1878-5891</identifier><identifier>DOI: 10.1016/0378-5955(95)00119-5</identifier><identifier>PMID: 8600130</identifier><identifier>CODEN: HERED3</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; Anti-Bacterial Agents - toxicity ; Biological and medical sciences ; Chicken ; Chickens ; Cochlea - drug effects ; Cochlea - injuries ; Cochlea - physiopathology ; Cochlear microphonic ; Cochlear Microphonic Potentials - drug effects ; Cochlear Microphonic Potentials - physiology ; Compound action potential ; Drug toxicity and drugs side effects treatment ; Endocochlear potential ; Evoked Potentials, Auditory - drug effects ; Evoked Potentials, Auditory - physiology ; Female ; Hair cell regeneration ; Hair Cells, Auditory - drug effects ; Hair Cells, Auditory - physiopathology ; Kanamycin ; Kanamycin - toxicity ; Medical sciences ; Ototoxicity ; Pharmacology. Drug treatments ; Regeneration ; Time Factors ; Toxicity: respiratory system, ent, stomatology ; Vestibulocochlear Nerve - drug effects ; Vestibulocochlear Nerve - physiopathology ; Vestibulocochlear Nerve Injuries</subject><ispartof>Hearing research, 1995-09, Vol.89 (1), p.28-34</ispartof><rights>1995</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-6fb36dcc48937795652e43afee2f476c4e7d511ca8a6f242c30869142d6f22aa3</citedby><cites>FETCH-LOGICAL-c417t-6fb36dcc48937795652e43afee2f476c4e7d511ca8a6f242c30869142d6f22aa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0378-5955(95)00119-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2938284$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8600130$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Lin</creatorcontrib><creatorcontrib>Trautwein, Patricia G.</creatorcontrib><creatorcontrib>Miller, Karen</creatorcontrib><creatorcontrib>Salvi, Richard J.</creatorcontrib><title>Effects of kanamycin ototoxicity and hair cell regeneration on the DC endocochlear potential in adult chickens</title><title>Hearing research</title><addtitle>Hear Res</addtitle><description>High doses of aminoglycoside antibiotics cause massive damage to the avian basilar papilla. The resulting functional loss could conceivably arise from the reduction in the DC endocochlear potential (EP) due to impairment of the tegmentum vasculosum (TV) or to shunting of current through the damaged sensory epithelium. To test this hypothesis, the EP was measured in adult chickens after destroying hair cells in the basal half of the cochlea with a high dose (400 mg/kg per day for 10 days) of kanamycin (KM). KM treatment caused an increase in the steady-state EP from +18.1 to +23.3 mV and a decrease in the magnitude of the negative EP from −42.0 to −19.2 mV. The EP showed almost no change between 1 and 2 days and 1 week post-KM treatment. After 4 weeks of recovery, most hair cells had regenerated; however, the steady-state EP was still elevated by 13% and the negative EP was depressed by 37%. These results suggest that functional loss as shown by the large reduction in cochlear microphonic (CM) and the elevated thresholds of compound action potential (CAP) following KM treatment is not due to a reduction in the EP but may arise from functional deficits in the hair cells and/or the auditory nerve.</description><subject>Animals</subject><subject>Anti-Bacterial Agents - toxicity</subject><subject>Biological and medical sciences</subject><subject>Chicken</subject><subject>Chickens</subject><subject>Cochlea - drug effects</subject><subject>Cochlea - injuries</subject><subject>Cochlea - physiopathology</subject><subject>Cochlear microphonic</subject><subject>Cochlear Microphonic Potentials - drug effects</subject><subject>Cochlear Microphonic Potentials - physiology</subject><subject>Compound action potential</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Endocochlear potential</subject><subject>Evoked Potentials, Auditory - drug effects</subject><subject>Evoked Potentials, Auditory - physiology</subject><subject>Female</subject><subject>Hair cell regeneration</subject><subject>Hair Cells, Auditory - drug effects</subject><subject>Hair Cells, Auditory - physiopathology</subject><subject>Kanamycin</subject><subject>Kanamycin - toxicity</subject><subject>Medical sciences</subject><subject>Ototoxicity</subject><subject>Pharmacology. Drug treatments</subject><subject>Regeneration</subject><subject>Time Factors</subject><subject>Toxicity: respiratory system, ent, stomatology</subject><subject>Vestibulocochlear Nerve - drug effects</subject><subject>Vestibulocochlear Nerve - physiopathology</subject><subject>Vestibulocochlear Nerve Injuries</subject><issn>0378-5955</issn><issn>1878-5891</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2PFCEQhonRrLOr_0ATDsash9amge7msokZ149kEy96JrXVhYPbAyMwxvn30s5kjoYDH_XUG3hg7IVo34pW9O9aOYyNNlpfG_2mbYUwjX7EVmJcjkcjHrPVGXnKLnP-WSEtVXfBLsa-rmW7YuHWOcKSeXT8AQJsD-gDj6WOPx59OXAIE9-ATxxpnnmiHxQoQfGxYoGXDfEPa05hihhxMxMkvouFQvEw8xoF034uHDceHyjkZ-yJgznT89N8xb5_vP22_tzcff30Zf3-rkElhtL07l72E6IajRwGo3vdkZLgiDqnhh4VDZMWAmGE3nWqQ9mOvRGqm-q2A5BX7PUxd5firz3lYrc-Lw-AQHGfreiNUVKLCqojiCnmnMjZXfJbSAcrWrtototDuzi0Rtt_mq2ubS9P-fv7LU3nppPXWn91qkNGmF2CgD6fsc7IsRtVxW6OGFUXvz0lm9FTQJp8qr9ip-j_f4-_phSZvQ</recordid><startdate>19950901</startdate><enddate>19950901</enddate><creator>Chen, Lin</creator><creator>Trautwein, Patricia G.</creator><creator>Miller, Karen</creator><creator>Salvi, Richard J.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>19950901</creationdate><title>Effects of kanamycin ototoxicity and hair cell regeneration on the DC endocochlear potential in adult chickens</title><author>Chen, Lin ; Trautwein, Patricia G. ; Miller, Karen ; Salvi, Richard J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-6fb36dcc48937795652e43afee2f476c4e7d511ca8a6f242c30869142d6f22aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Anti-Bacterial Agents - toxicity</topic><topic>Biological and medical sciences</topic><topic>Chicken</topic><topic>Chickens</topic><topic>Cochlea - drug effects</topic><topic>Cochlea - injuries</topic><topic>Cochlea - physiopathology</topic><topic>Cochlear microphonic</topic><topic>Cochlear Microphonic Potentials - drug effects</topic><topic>Cochlear Microphonic Potentials - physiology</topic><topic>Compound action potential</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Endocochlear potential</topic><topic>Evoked Potentials, Auditory - drug effects</topic><topic>Evoked Potentials, Auditory - physiology</topic><topic>Female</topic><topic>Hair cell regeneration</topic><topic>Hair Cells, Auditory - drug effects</topic><topic>Hair Cells, Auditory - physiopathology</topic><topic>Kanamycin</topic><topic>Kanamycin - toxicity</topic><topic>Medical sciences</topic><topic>Ototoxicity</topic><topic>Pharmacology. Drug treatments</topic><topic>Regeneration</topic><topic>Time Factors</topic><topic>Toxicity: respiratory system, ent, stomatology</topic><topic>Vestibulocochlear Nerve - drug effects</topic><topic>Vestibulocochlear Nerve - physiopathology</topic><topic>Vestibulocochlear Nerve Injuries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Lin</creatorcontrib><creatorcontrib>Trautwein, Patricia G.</creatorcontrib><creatorcontrib>Miller, Karen</creatorcontrib><creatorcontrib>Salvi, Richard J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Hearing research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Lin</au><au>Trautwein, Patricia G.</au><au>Miller, Karen</au><au>Salvi, Richard J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of kanamycin ototoxicity and hair cell regeneration on the DC endocochlear potential in adult chickens</atitle><jtitle>Hearing research</jtitle><addtitle>Hear Res</addtitle><date>1995-09-01</date><risdate>1995</risdate><volume>89</volume><issue>1</issue><spage>28</spage><epage>34</epage><pages>28-34</pages><issn>0378-5955</issn><eissn>1878-5891</eissn><coden>HERED3</coden><abstract>High doses of aminoglycoside antibiotics cause massive damage to the avian basilar papilla. The resulting functional loss could conceivably arise from the reduction in the DC endocochlear potential (EP) due to impairment of the tegmentum vasculosum (TV) or to shunting of current through the damaged sensory epithelium. To test this hypothesis, the EP was measured in adult chickens after destroying hair cells in the basal half of the cochlea with a high dose (400 mg/kg per day for 10 days) of kanamycin (KM). KM treatment caused an increase in the steady-state EP from +18.1 to +23.3 mV and a decrease in the magnitude of the negative EP from −42.0 to −19.2 mV. The EP showed almost no change between 1 and 2 days and 1 week post-KM treatment. After 4 weeks of recovery, most hair cells had regenerated; however, the steady-state EP was still elevated by 13% and the negative EP was depressed by 37%. These results suggest that functional loss as shown by the large reduction in cochlear microphonic (CM) and the elevated thresholds of compound action potential (CAP) following KM treatment is not due to a reduction in the EP but may arise from functional deficits in the hair cells and/or the auditory nerve.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>8600130</pmid><doi>10.1016/0378-5955(95)00119-5</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-5955 |
| ispartof | Hearing research, 1995-09, Vol.89 (1), p.28-34 |
| issn | 0378-5955 1878-5891 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_16994351 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Anti-Bacterial Agents - toxicity Biological and medical sciences Chicken Chickens Cochlea - drug effects Cochlea - injuries Cochlea - physiopathology Cochlear microphonic Cochlear Microphonic Potentials - drug effects Cochlear Microphonic Potentials - physiology Compound action potential Drug toxicity and drugs side effects treatment Endocochlear potential Evoked Potentials, Auditory - drug effects Evoked Potentials, Auditory - physiology Female Hair cell regeneration Hair Cells, Auditory - drug effects Hair Cells, Auditory - physiopathology Kanamycin Kanamycin - toxicity Medical sciences Ototoxicity Pharmacology. Drug treatments Regeneration Time Factors Toxicity: respiratory system, ent, stomatology Vestibulocochlear Nerve - drug effects Vestibulocochlear Nerve - physiopathology Vestibulocochlear Nerve Injuries |
| title | Effects of kanamycin ototoxicity and hair cell regeneration on the DC endocochlear potential in adult chickens |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T20%3A38%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20kanamycin%20ototoxicity%20and%20hair%20cell%20regeneration%20on%20the%20DC%20endocochlear%20potential%20in%20adult%20chickens&rft.jtitle=Hearing%20research&rft.au=Chen,%20Lin&rft.date=1995-09-01&rft.volume=89&rft.issue=1&rft.spage=28&rft.epage=34&rft.pages=28-34&rft.issn=0378-5955&rft.eissn=1878-5891&rft.coden=HERED3&rft_id=info:doi/10.1016/0378-5955(95)00119-5&rft_dat=%3Cproquest_cross%3E16994351%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16994351&rft_id=info:pmid/8600130&rft_els_id=0378595595001195&rfr_iscdi=true |