Variants of Tissue-type Plasminogen Activator with Substantially Enhanced Response and Selectivity toward Fibrin Co-factors (∗)

Unlike most proteases, tissue-type plasminogen activator (t-PA) is not synthesized as an inactive precursor or zymogen. Instead, the single-chain “proenzyme” form of t-PA possesses very significant catalytic activity. Recent investigations of the molecular basis of the unusually high enzymatic activ...

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