Modulation of central glucocorticoid receptors in short- and long-term experimental hyperthyroidism

Hyperthyroidism is associated with a significant increase in circulating glucocorticoid levels and hyperactivity of the hypothalamic–pituitary–adrenal (HPA) axis. The aim of this study was to examine whether the HPA axis hyperactivity observed in hyperthyroidism may be explained by a disturbed feedb...

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Veröffentlicht in:	Endocrine 2015-08, Vol.49 (3), p.828-841
Hauptverfasser:	Nikolopoulou, Elena, Mytilinaios, Dimitrios, Calogero, Aldo E., Kamilaris, Themis C., Troupis, Theodore, Chrousos, George P., Johnson, Elizabeth O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Animals Chronic Disease Cytosol - metabolism Diabetes Endocrinology Gene Expression - genetics Hippocampus - drug effects Hippocampus - metabolism Humanities and Social Sciences Hyperthyroidism - metabolism Hypothalamo-Hypophyseal System - metabolism Internal Medicine Male Medicine Medicine & Public Health multidisciplinary Original Article Pituitary Gland, Anterior - drug effects Pituitary Gland, Anterior - metabolism Pituitary-Adrenal System - metabolism Rats Rats, Sprague-Dawley Receptors, Glucocorticoid - biosynthesis Receptors, Glucocorticoid - genetics Receptors, Glucocorticoid - metabolism Receptors, Mineralocorticoid - metabolism Saline Solution, Hypertonic Science Thyroxine - pharmacology
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