Comparative Study of Clinical and Neuropsychological Characteristics Between Early-, Late and Very-Late-Onset Schizophrenia-Spectrum Disorders
Objective To compare the clinical and neurocognitive profile of early-onset (EOP,
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| Veröffentlicht in: | The American journal of geriatric psychiatry 2015-08, Vol.23 (8), p.852-862 |
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| creator | Hanssen, Manon, Ph.D van der Werf, Margriet, M.D., Ph.D Verkaaik, Mike, M.D Arts, Baer, M.D., Ph.D Myin-Germeys, Inez, Ph.D van Os, Jim, M.D., Ph.D Verhey, Frans, M.D., Ph.D Köhler, Sebastian, Ph.D |
| description | Objective To compare the clinical and neurocognitive profile of early-onset (EOP, |
| doi_str_mv | 10.1016/j.jagp.2014.10.007 |
| format | Article |
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Design Cross-sectional observational study. Setting Secondary, tertiary, and community mental health care. Participants Patients with a DSM-IV diagnosis of non-affective psychotic disorder were included from two complementary studies (GROUP and PSITE) on genetic and environmental risk factors of psychosis in the Netherlands and Belgium. Measurements Main outcome measures were the severity of positive and negative symptoms, quality of life, and age-corrected scores on measures of general intelligence, verbal memory, attention, and executive function. One-year follow-up data were used to validate diagnoses and exclude participants with possible or probable dementia. Results 286 EOP (85%), 24 LOP (7%) and 28 VLOP (8%) participated. VLOP patients reported significantly more positive symptoms than EOP patients. Age-at-onset groups had similar age-corrected scores on IQ, verbal memory, attention and executive functions. A significantly better performance was found in VLOP compared with LOP on the CAMCOG total score, though scores were still within the normal range. After controlling for possible confounding, however, VLOP differed significantly on an attention accuracy task compared with LOP patients. Re-entering data for probable dementia patients (N = 4) did change the results regarding cognition outcomes. Conclusions VLOP patients show more positive symptoms but do not appear to differ on neuropsychological tests from EOP and LOP when age is controlled for. This questions the idea that VLOP is the expression of underlying neurodegeneration.</description><identifier>ISSN: 1064-7481</identifier><identifier>EISSN: 1545-7214</identifier><identifier>DOI: 10.1016/j.jagp.2014.10.007</identifier><identifier>PMID: 25500119</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Age of Onset ; Aged ; Aged, 80 and over ; Belgium ; clinical phenotype ; cognition ; Cross-Sectional Studies ; Dementia - diagnosis ; Diagnostic and Statistical Manual of Mental Disorders ; Executive Function ; Female ; Humans ; Internal Medicine ; late-onset psychosis ; Late-onset schizophrenia-spectrum disorders ; Male ; Middle Aged ; Multivariate Analysis ; Netherlands ; Neuropsychological Tests ; neuropsychology ; Psychiatric Status Rating Scales ; Quality of Life ; Reference Values ; Schizophrenia - complications ; Schizophrenia - diagnosis ; Young Adult</subject><ispartof>The American journal of geriatric psychiatry, 2015-08, Vol.23 (8), p.852-862</ispartof><rights>American Association for Geriatric Psychiatry</rights><rights>2015 American Association for Geriatric Psychiatry</rights><rights>Copyright © 2015 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-12b692d78284b0d5ea117bd4be77bbc141f2a156475ec7ce69def3e03a669a0b3</citedby><cites>FETCH-LOGICAL-c411t-12b692d78284b0d5ea117bd4be77bbc141f2a156475ec7ce69def3e03a669a0b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25500119$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hanssen, Manon, Ph.D</creatorcontrib><creatorcontrib>van der Werf, Margriet, M.D., Ph.D</creatorcontrib><creatorcontrib>Verkaaik, Mike, M.D</creatorcontrib><creatorcontrib>Arts, Baer, M.D., Ph.D</creatorcontrib><creatorcontrib>Myin-Germeys, Inez, Ph.D</creatorcontrib><creatorcontrib>van Os, Jim, M.D., Ph.D</creatorcontrib><creatorcontrib>Verhey, Frans, M.D., Ph.D</creatorcontrib><creatorcontrib>Köhler, Sebastian, Ph.D</creatorcontrib><creatorcontrib>Genetic Risk and Outcome in Psychosis study group</creatorcontrib><title>Comparative Study of Clinical and Neuropsychological Characteristics Between Early-, Late and Very-Late-Onset Schizophrenia-Spectrum Disorders</title><title>The American journal of geriatric psychiatry</title><addtitle>Am J Geriatr Psychiatry</addtitle><description>Objective To compare the clinical and neurocognitive profile of early-onset (EOP, <40 years), late-onset (LOP, 40–59 years) and very-late-onset (VLOP, ≥60 years) psychosis. Design Cross-sectional observational study. Setting Secondary, tertiary, and community mental health care. Participants Patients with a DSM-IV diagnosis of non-affective psychotic disorder were included from two complementary studies (GROUP and PSITE) on genetic and environmental risk factors of psychosis in the Netherlands and Belgium. Measurements Main outcome measures were the severity of positive and negative symptoms, quality of life, and age-corrected scores on measures of general intelligence, verbal memory, attention, and executive function. One-year follow-up data were used to validate diagnoses and exclude participants with possible or probable dementia. Results 286 EOP (85%), 24 LOP (7%) and 28 VLOP (8%) participated. VLOP patients reported significantly more positive symptoms than EOP patients. Age-at-onset groups had similar age-corrected scores on IQ, verbal memory, attention and executive functions. A significantly better performance was found in VLOP compared with LOP on the CAMCOG total score, though scores were still within the normal range. After controlling for possible confounding, however, VLOP differed significantly on an attention accuracy task compared with LOP patients. Re-entering data for probable dementia patients (N = 4) did change the results regarding cognition outcomes. Conclusions VLOP patients show more positive symptoms but do not appear to differ on neuropsychological tests from EOP and LOP when age is controlled for. This questions the idea that VLOP is the expression of underlying neurodegeneration.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age of Onset</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Belgium</subject><subject>clinical phenotype</subject><subject>cognition</subject><subject>Cross-Sectional Studies</subject><subject>Dementia - diagnosis</subject><subject>Diagnostic and Statistical Manual of Mental Disorders</subject><subject>Executive Function</subject><subject>Female</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>late-onset psychosis</subject><subject>Late-onset schizophrenia-spectrum disorders</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Netherlands</subject><subject>Neuropsychological Tests</subject><subject>neuropsychology</subject><subject>Psychiatric Status Rating Scales</subject><subject>Quality of Life</subject><subject>Reference Values</subject><subject>Schizophrenia - complications</subject><subject>Schizophrenia - diagnosis</subject><subject>Young Adult</subject><issn>1064-7481</issn><issn>1545-7214</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UsuO1DAQjBCIXRZ-gAPKkQMZ3IljJxJCgrA8pBF7GOBqOXZnxyETZ21nUfgIvhlnZ-DAgVO7S1UluaqT5CmQDRBgL_tNL6-nTU6ARmBDCL-XnENJy4znQO_HN2E047SCs-SR9z0hhNWMPkzO8rIkBKA-T3419jBJJ4O5xXQXZr2ktkubwYxGySGVo04_4-zs5Be1t4O9voObfZSogM74YJRP32L4gTiml9INS_Yi3cqAd9pv6JZs3bKr0WNId2pvftpp73A0MttNqIKbD-k7463T6Pzj5EEnB49PTvMi-fr-8kvzMdteffjUvNlmigKEDPKW1bnmVV7RlugSJQBvNW2R87ZVQKHLJZSM8hIVV8hqjV2BpJCM1ZK0xUXy_Og7OXszow_iYLzCYZAj2tkLYHVVsxKqKlLzI1U5673DTkzOHKRbBBCx9iB6sfYg1h5WLPYQRc9O_nN7QP1X8if4SHh1JGD85a1BJ7wyOCrUxsVQhLbm__6v_5GrU2XfcUHf29mNMT8BwueCiN16CeshACWkAE6K34YAsJ4</recordid><startdate>20150801</startdate><enddate>20150801</enddate><creator>Hanssen, Manon, Ph.D</creator><creator>van der Werf, Margriet, M.D., Ph.D</creator><creator>Verkaaik, Mike, M.D</creator><creator>Arts, Baer, M.D., Ph.D</creator><creator>Myin-Germeys, Inez, Ph.D</creator><creator>van Os, Jim, M.D., Ph.D</creator><creator>Verhey, Frans, M.D., Ph.D</creator><creator>Köhler, Sebastian, Ph.D</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150801</creationdate><title>Comparative Study of Clinical and Neuropsychological Characteristics Between Early-, Late and Very-Late-Onset Schizophrenia-Spectrum Disorders</title><author>Hanssen, Manon, Ph.D ; van der Werf, Margriet, M.D., Ph.D ; Verkaaik, Mike, M.D ; Arts, Baer, M.D., Ph.D ; Myin-Germeys, Inez, Ph.D ; van Os, Jim, M.D., Ph.D ; Verhey, Frans, M.D., Ph.D ; Köhler, Sebastian, Ph.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-12b692d78284b0d5ea117bd4be77bbc141f2a156475ec7ce69def3e03a669a0b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age of Onset</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Belgium</topic><topic>clinical phenotype</topic><topic>cognition</topic><topic>Cross-Sectional Studies</topic><topic>Dementia - diagnosis</topic><topic>Diagnostic and Statistical Manual of Mental Disorders</topic><topic>Executive Function</topic><topic>Female</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>late-onset psychosis</topic><topic>Late-onset schizophrenia-spectrum disorders</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Netherlands</topic><topic>Neuropsychological Tests</topic><topic>neuropsychology</topic><topic>Psychiatric Status Rating Scales</topic><topic>Quality of Life</topic><topic>Reference Values</topic><topic>Schizophrenia - complications</topic><topic>Schizophrenia - diagnosis</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hanssen, Manon, Ph.D</creatorcontrib><creatorcontrib>van der Werf, Margriet, M.D., Ph.D</creatorcontrib><creatorcontrib>Verkaaik, Mike, M.D</creatorcontrib><creatorcontrib>Arts, Baer, M.D., Ph.D</creatorcontrib><creatorcontrib>Myin-Germeys, Inez, Ph.D</creatorcontrib><creatorcontrib>van Os, Jim, M.D., Ph.D</creatorcontrib><creatorcontrib>Verhey, Frans, M.D., Ph.D</creatorcontrib><creatorcontrib>Köhler, Sebastian, Ph.D</creatorcontrib><creatorcontrib>Genetic Risk and Outcome in Psychosis study group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of geriatric psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hanssen, Manon, Ph.D</au><au>van der Werf, Margriet, M.D., Ph.D</au><au>Verkaaik, Mike, M.D</au><au>Arts, Baer, M.D., Ph.D</au><au>Myin-Germeys, Inez, Ph.D</au><au>van Os, Jim, M.D., Ph.D</au><au>Verhey, Frans, M.D., Ph.D</au><au>Köhler, Sebastian, Ph.D</au><aucorp>Genetic Risk and Outcome in Psychosis study group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative Study of Clinical and Neuropsychological Characteristics Between Early-, Late and Very-Late-Onset Schizophrenia-Spectrum Disorders</atitle><jtitle>The American journal of geriatric psychiatry</jtitle><addtitle>Am J Geriatr Psychiatry</addtitle><date>2015-08-01</date><risdate>2015</risdate><volume>23</volume><issue>8</issue><spage>852</spage><epage>862</epage><pages>852-862</pages><issn>1064-7481</issn><eissn>1545-7214</eissn><abstract>Objective To compare the clinical and neurocognitive profile of early-onset (EOP, <40 years), late-onset (LOP, 40–59 years) and very-late-onset (VLOP, ≥60 years) psychosis. Design Cross-sectional observational study. Setting Secondary, tertiary, and community mental health care. Participants Patients with a DSM-IV diagnosis of non-affective psychotic disorder were included from two complementary studies (GROUP and PSITE) on genetic and environmental risk factors of psychosis in the Netherlands and Belgium. Measurements Main outcome measures were the severity of positive and negative symptoms, quality of life, and age-corrected scores on measures of general intelligence, verbal memory, attention, and executive function. One-year follow-up data were used to validate diagnoses and exclude participants with possible or probable dementia. Results 286 EOP (85%), 24 LOP (7%) and 28 VLOP (8%) participated. VLOP patients reported significantly more positive symptoms than EOP patients. Age-at-onset groups had similar age-corrected scores on IQ, verbal memory, attention and executive functions. A significantly better performance was found in VLOP compared with LOP on the CAMCOG total score, though scores were still within the normal range. After controlling for possible confounding, however, VLOP differed significantly on an attention accuracy task compared with LOP patients. Re-entering data for probable dementia patients (N = 4) did change the results regarding cognition outcomes. Conclusions VLOP patients show more positive symptoms but do not appear to differ on neuropsychological tests from EOP and LOP when age is controlled for. This questions the idea that VLOP is the expression of underlying neurodegeneration.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>25500119</pmid><doi>10.1016/j.jagp.2014.10.007</doi><tpages>11</tpages></addata></record> |
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| subjects | Adolescent Adult Age of Onset Aged Aged, 80 and over Belgium clinical phenotype cognition Cross-Sectional Studies Dementia - diagnosis Diagnostic and Statistical Manual of Mental Disorders Executive Function Female Humans Internal Medicine late-onset psychosis Late-onset schizophrenia-spectrum disorders Male Middle Aged Multivariate Analysis Netherlands Neuropsychological Tests neuropsychology Psychiatric Status Rating Scales Quality of Life Reference Values Schizophrenia - complications Schizophrenia - diagnosis Young Adult |
| title | Comparative Study of Clinical and Neuropsychological Characteristics Between Early-, Late and Very-Late-Onset Schizophrenia-Spectrum Disorders |
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